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HomeProduct name listVanillic acid

Vanillic acid

Synonym(s):4-Hydroxy-3-methoxybenzoic acid;Vanillic acid

  • CAS NO.:121-34-6
  • Empirical Formula: C8H8O4
  • Molecular Weight: 168.15
  • MDL number: MFCD00002551
  • EINECS: 204-466-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2025-01-27 09:38:02
Vanillic acid  Structural

What is Vanillic acid ?

Chemical properties

white odourless crystals or powder

Chemical properties

4-Hydroxy-3-methoxybenzoic acid has a vanilla-like odor and taste.

Occurrence

Reported found in guava, grape, brandy, rum, whiskey, sherry, red and white wines, Scotch and Canadian whiskey, pork (fried), cocoa, peanuts (raw), mushrooms, guava fruit, mangos (fresh), wort, vanilla and black chokeberries.

The Uses of Vanillic acid

Vanillic acid is used as a flavoring agent in food. It acts as an intermediate in the production of vanillin from ferulic acid. Further, it is used in wine and vinegar.

The Uses of Vanillic acid

Vanillin, a compound widely used in foods, beverages, cosmetics and drugs, has been reported to exhibit multifunctional effects such as antimutagenic, antiangiogenetic, anti-colitis, anti-sickling, an d antianalgesic effects. However, results of studies on the antioxidant activity of vanillin are not consistent.

The Uses of Vanillic acid

A flavoring agent.

What are the applications of Application

Vanillic acid is a flavoring agent

Definition

ChEBI: A monohydroxybenzoic acid that is 4-hydroxybenzoic acid substituted by a methoxy group at position 3.

Preparation

Prepared by bioconversion of ferulic acid by means of a vanillate-negative mutant of Pseudomonas fluorescens strain BS13. Also prepared by whole-cell bioconversion of vanillin to vanillic acid by Streptomyces viridosporus

Aroma threshold values

Aroma at 5.0%: weak vanilla, creamy, milky.

Taste threshold values

Taste characteristics at 100 ppm: weak sweet resinous vanilla, creamy with a smooth sweetness and body, slightly chocolate-like with a spicy vanitrop nuance

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 429, 1946 DOI: 10.1021/ja01207a025
Organic Syntheses, Coll. Vol. 4, p. 972, 1963

General Description

Vanillic acid is one of the key aromatic volatile compounds of vanilla beans.

Biochem/physiol Actions

Taste at 100 ppm

Properties of Vanillic acid

Melting point: 208-210 °C(lit.)
Boiling point: 257.07°C (rough estimate)
Density  1.3037 (rough estimate)
refractive index  1.5090 (estimate)
FEMA  3988 | 4-HYDROXY-3-METHOXYBENZOIC ACID
storage temp.  Store below +30°C.
solubility  Acetonitrile (Slightly), Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly)
pka pKa 4.53(H2O t = 25 c = 0.016–0.001) (Uncertain)
form  Liquid
color  Clear colorless to brown, may darken during storage
Odor at 100.00 %. dairy milky custard creamy powdery vanilla bean
Water Solubility  Soluble in water, alcohol and ether.
JECFA Number 959
Merck  14,9931
BRN  2208364
Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference 121-34-6(CAS DataBase Reference)
NIST Chemistry Reference Benzoic acid, 4-hydroxy-3-methoxy-(121-34-6)
EPA Substance Registry System Vanillic acid (121-34-6)

Safety information for Vanillic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for Vanillic acid

InChIKey WKOLLVMJNQIZCI-UHFFFAOYSA-N

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