Vanillic acid
Synonym(s):4-Hydroxy-3-methoxybenzoic acid;Vanillic acid
- CAS NO.:121-34-6
- Empirical Formula: C8H8O4
- Molecular Weight: 168.15
- MDL number: MFCD00002551
- EINECS: 204-466-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-01-27 09:38:02
What is Vanillic acid ?
Chemical properties
white odourless crystals or powder
Chemical properties
4-Hydroxy-3-methoxybenzoic acid has a vanilla-like odor and taste.
Occurrence
Reported found in guava, grape, brandy, rum, whiskey, sherry, red and white wines, Scotch and Canadian whiskey, pork (fried), cocoa, peanuts (raw), mushrooms, guava fruit, mangos (fresh), wort, vanilla and black chokeberries.
The Uses of Vanillic acid
Vanillic acid is used as a flavoring agent in food. It acts as an intermediate in the production of vanillin from ferulic acid. Further, it is used in wine and vinegar.
The Uses of Vanillic acid
Vanillin, a compound widely used in foods, beverages, cosmetics and drugs, has been reported to exhibit multifunctional effects such as antimutagenic, antiangiogenetic, anti-colitis, anti-sickling, an d antianalgesic effects. However, results of studies on the antioxidant activity of vanillin are not consistent.
The Uses of Vanillic acid
A flavoring agent.
What are the applications of Application
Vanillic acid is a flavoring agent
Definition
ChEBI: A monohydroxybenzoic acid that is 4-hydroxybenzoic acid substituted by a methoxy group at position 3.
Preparation
Prepared by bioconversion of ferulic acid by means of a vanillate-negative mutant of Pseudomonas fluorescens strain BS13. Also prepared by whole-cell bioconversion of vanillin to vanillic acid by Streptomyces viridosporus
Aroma threshold values
Aroma at 5.0%: weak vanilla, creamy, milky.
Taste threshold values
Taste characteristics at 100 ppm: weak sweet resinous vanilla, creamy with a smooth sweetness and body, slightly chocolate-like with a spicy vanitrop nuance
Synthesis Reference(s)
Journal of the American Chemical Society, 68, p. 429, 1946 DOI: 10.1021/ja01207a025
Organic Syntheses, Coll. Vol. 4, p. 972, 1963
General Description
Vanillic acid is one of the key aromatic volatile compounds of vanilla beans.
Biochem/physiol Actions
Taste at 100 ppm
Properties of Vanillic acid
Melting point: | 208-210 °C(lit.) |
Boiling point: | 257.07°C (rough estimate) |
Density | 1.3037 (rough estimate) |
refractive index | 1.5090 (estimate) |
FEMA | 3988 | 4-HYDROXY-3-METHOXYBENZOIC ACID |
storage temp. | Store below +30°C. |
solubility | Acetonitrile (Slightly), Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly) |
pka | pKa 4.53(H2O
t = 25
c = 0.016–0.001) (Uncertain) |
form | Liquid |
color | Clear colorless to brown, may darken during storage |
Odor | at 100.00 %. dairy milky custard creamy powdery vanilla bean |
Water Solubility | Soluble in water, alcohol and ether. |
JECFA Number | 959 |
Merck | 14,9931 |
BRN | 2208364 |
Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
CAS DataBase Reference | 121-34-6(CAS DataBase Reference) |
NIST Chemistry Reference | Benzoic acid, 4-hydroxy-3-methoxy-(121-34-6) |
EPA Substance Registry System | Vanillic acid (121-34-6) |
Safety information for Vanillic acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Vanillic acid
InChIKey | WKOLLVMJNQIZCI-UHFFFAOYSA-N |
Vanillic acid manufacturer
Synocule Research Labs Pvt Ltd
GRK RESEARCH LABORATORIES PVT LTD
BASR Fine Chemicals Pvt. Ltd.
Blue Jet Healthcare Ltd
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