Hexamethylphosphorous triamide
Synonym(s):(Me2N)3P;Hexamethylphosphorous triamide;Hexamethyltriamidophosphite;Hexamethyltriaminophosphine;HMPT
- CAS NO.：1608-26-0
- Empirical Formula: C6H18N3P
- Molecular Weight: 163.2
- MDL number: MFCD00008301
- EINECS: 216-534-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-11 17:04:31
What is Hexamethylphosphorous triamide?
Chemical properties
colourless liquid
The Uses of Hexamethylphosphorous triamide
Hexamethylphosphorous triamide can be widely used in industry, with applications such as being a flame retardant for building materials to a phosphorylating agent in synthetic chemistry. It is a classified carcinogen.
The Uses of Hexamethylphosphorous triamide
Hexamethylphosphorous triamide can be uesd in suzuki reaction.
The Uses of Hexamethylphosphorous triamide
Hexamethylphosphorous triamide can be combination with CCl4 for the conversion of hydroxyl groups to the corresponding chlorides; hydroxyl group activation; dehydrations.
What are the applications of Application
Tris(dimethylamino)phosphine is a common synthesis reagent for the chloride substitution of hydroxy groups
Purification Methods
It may contain more than 1% of phosphoric triamide. The yellow oil is first distilled at atmospheric pressure, then under reduced pressure and stored under N2. It is air sensitive, TOXIC, and should not be inhaled. It is absorbed through the skin. [Mark Org Synth Coll Vol V 602 1973, Beilstein 4 IV 274.]
Properties of Hexamethylphosphorous triamide
| Melting point: | -44 °C |
| Boiling point: | 48-50 °C/12 mmHg (lit.) |
| Density | 0.898 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 73 °F |
| storage temp. | Inert atmosphere,2-8°C |
| form | Liquid |
| pka | 8.03±0.70(Predicted) |
| Specific Gravity | 0.8980 |
| color | Clear colorless to slightly yellow |
| Water Solubility | REACTS |
| Sensitive | Moisture Sensitive |
| BRN | 906778 |
| Stability: | Stable. Highly flammable - note low flash point. Incompatible with oxidizing agents. |
| CAS DataBase Reference | 1608-26-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Phosphorous triamide, hexamethyl-(1608-26-0) |
| EPA Substance Registry System | Phosphorous triamide, hexamethyl- (1608-26-0) |
Safety information for Hexamethylphosphorous triamide
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H340:Germ cell mutagenicity H350:Carcinogenicity |
| Precautionary Statement Codes |
P202:Do not handle until all safety precautions have been read and understood. P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for Hexamethylphosphorous triamide
| InChIKey | XVDBWWRIXBMVJV-UHFFFAOYSA-N |
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