Hexamethylphosphorous triamide

Synonym(s):(Me₂N)₃P;Hexamethylphosphorous triamide;Hexamethyltriamidophosphite;Hexamethyltriaminophosphine;HMPT

CAS NO.：1608-26-0
Empirical Formula: C6H18N3P
Molecular Weight: 163.2
MDL number: MFCD00008301
EINECS: 216-534-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-11 17:04:31

Hexamethylphosphorous triamide Structural

What is Hexamethylphosphorous triamide?

Chemical properties

colourless liquid

The Uses of Hexamethylphosphorous triamide

Hexamethylphosphorous triamide can be widely used in industry, with applications such as being a flame retardant for building materials to a phosphorylating agent in synthetic chemistry. It is a classified carcinogen.

The Uses of Hexamethylphosphorous triamide

Hexamethylphosphorous triamide can be uesd in suzuki reaction.

The Uses of Hexamethylphosphorous triamide

Hexamethylphosphorous triamide can be combination with CCl4 for the conversion of hydroxyl groups to the corresponding chlorides; hydroxyl group activation; dehydrations.

What are the applications of Application

Tris(dimethylamino)phosphine is a common synthesis reagent for the chloride substitution of hydroxy groups

Purification Methods

It may contain more than 1% of phosphoric triamide. The yellow oil is first distilled at atmospheric pressure, then under reduced pressure and stored under N2. It is air sensitive, TOXIC, and should not be inhaled. It is absorbed through the skin. [Mark Org Synth Coll Vol V 602 1973, Beilstein 4 IV 274.]

Properties of Hexamethylphosphorous triamide

Melting point:	-44 °C
Boiling point:	48-50 °C/12 mmHg (lit.)
Density	0.898 g/mL at 25 °C (lit.)
refractive index	n20/D 1.463(lit.)
Flash point:	73 °F
storage temp.	Inert atmosphere,2-8°C
form	Liquid
pka	8.03±0.70(Predicted)
Specific Gravity	0.8980
color	Clear colorless to slightly yellow
Water Solubility	REACTS
Sensitive	Moisture Sensitive
BRN	906778
Stability:	Stable. Highly flammable - note low flash point. Incompatible with oxidizing agents.
CAS DataBase Reference	1608-26-0(CAS DataBase Reference)
NIST Chemistry Reference	Phosphorous triamide, hexamethyl-(1608-26-0)
EPA Substance Registry System	Phosphorous triamide, hexamethyl- (1608-26-0)

Safety information for Hexamethylphosphorous triamide

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H340:Germ cell mutagenicity H350:Carcinogenicity
Precautionary Statement Codes	P202:Do not handle until all safety precautions have been read and understood. P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention.