HEXAAMMINECOBALT(III) CHLORIDE
Synonym(s):Cobalt hexammine trichloride;Hexaamminecobalt trichloride
- CAS NO.:10534-89-1
- Empirical Formula: Cl3CoH18N6
- Molecular Weight: 267.48
- MDL number: MFCD00036304
- EINECS: 234-103-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is HEXAAMMINECOBALT(III) CHLORIDE?
Chemical properties
solid
The Uses of HEXAAMMINECOBALT(III) CHLORIDE
Hexaamminecobalt(III) chloride is a component of structural biology methods, especially for DNA or RNA, where the positive ions stabilize the tertiary structure of the phosphate backbone, which favors to solve their structure by X-ray crystallography. It serves as an excellent antibacterial and antiviral property.
The Uses of HEXAAMMINECOBALT(III) CHLORIDE
As reagent for pyrophosphoric acid, for the estimation of phosphate.
Preparation
Synthesis of hexaamminecobalt(III) chloride
2CoCl2+10NH3+2NH4Cl+H2O2 →2[Co(NH3) 6]Cl3+2H2O
Reaction. Dissolve 2.5 g (10.5 mmol) of cobalt(II) chloride hexahydrate and 1.7 g (32 mmol) of ammonium chloride (about 195% excess) in 15 mL of distilled water. Add 0.5 g of activated charcoal and 23 mL (380 mmol) of concentrated aqueous ammonia (about 624% excess). Cool the reaction mixture to 0 oC in an ice bath. Slowly add 2 mL (19.5 mmol) of 30% hydrogen peroxide (about 271% excess), with stirring – maintain the temperature below 10°C. After the hydrogen peroxide has been added, heat the reaction mixture to 60°C for about 30 minutes. Cool the reaction mixture to 0 oC to cause precipitation of the product.
General Description
Hexammine cobalt(III) is considered an analog of fully solvated magnesium, capable of activating some enzymes that requires magnesium. It is useful in DNA condensation studies.
Purification Methods
It crystallises from warm water (8mL/g) on cooling. [Bjerrum & McReynolds Inorg Synth II 217 1946.]
Properties of HEXAAMMINECOBALT(III) CHLORIDE
Melting point: | 217 °C(lit.) |
Density | 1.71 g/mL at 25 °C(lit.) |
storage temp. | room temp |
solubility | Soluble in ammonia. |
form | Powder |
color | Orange to orange-brown |
Specific Gravity | 1.71 |
Water Solubility | Soluble in ammonia and water. |
Merck | 14,4675 |
Exposure limits | ACGIH: TWA 0.02 mg/m3 |
Stability: | Stable. Incompatible with strong oxidizing agents. |
CAS DataBase Reference | 10534-89-1(CAS DataBase Reference) |
EPA Substance Registry System | Cobalt(3+), hexaammine-, trichloride, (OC-6-11)- (10534-89-1) |
Safety information for HEXAAMMINECOBALT(III) CHLORIDE
Signal word | Danger |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H317:Sensitisation, Skin H334:Sensitisation, respiratory H351:Carcinogenicity H413:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for HEXAAMMINECOBALT(III) CHLORIDE
InChIKey | JXBGZYGSWFSYFI-UHFFFAOYSA-K |
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