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HomeProduct name listGlycidyl phenyl ether

Glycidyl phenyl ether

Synonym(s):2,3-Epoxypropyl phenyl ether;Glycidyl phenyl ether;Glycidyl phenyl ether, 1,2-Epoxy-3-phenoxypropane, Phenyl 2,3-epoxypropyl ether, Phenyl glycid ether;Phenyl glycidyl ether

  • CAS NO.:122-60-1
  • Empirical Formula: C9H10O2
  • Molecular Weight: 150.17
  • MDL number: MFCD00005133
  • EINECS: 204-557-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-10-07 14:06:06
Glycidyl phenyl ether Structural

What is Glycidyl phenyl ether?

Description

This monoglycidyl derivative is a reactive diluent in epoxy resins of the bisphenol A type. It is a component of epoxy paints, epoxy glues, and epoxy resins. Sensitization was observed in many professions, such as in construction workers, marble workers, ceramic workers, and in a shoemaker.

Chemical properties

Phenyl glycidyl ether, also known as glycidyl phenyl ether or PGE, is a clear liquid with a sweet odor that is considered unpleasant. It is soluble in ether and benzene, but insoluble in water. It has the ability to volatilize with water vapor. It is used in the production of epoxy resins, as a chemical intermediate, and as a stabilizer.

The Uses of Glycidyl phenyl ether

Phenyl glycidyl ether (PGE) is used as anintermediate in organic syntheses.

The Uses of Glycidyl phenyl ether

2-Phenylglycidyl ether is an organic synthesis; chemical intermediate with high solvency for halogenated materials; reactive diluent of epoxy-resin systems; forms chemical bonds with the resin during cure and accelerates the curing process.

Production Methods

PGE is synthesized by condensation of phenol with epichlorohydrin, with subsequent dehydrochlorination with caustic to form the epoxy ring.

Definition

ChEBI: Phenyl glycidyl ether is an aromatic ether.

Synthesis Reference(s)

The Journal of Organic Chemistry, 50, p. 1784, 1985 DOI: 10.1021/jo00210a053

General Description

Colorless liquid.

Air & Water Reactions

Ethers tend to form unstable peroxides when exposed to oxygen. Ethyl, isobutyl, ethyl tert-butyl, and ethyl tert-pentyl ether are particularly hazardous in this respect. Ether peroxides can sometimes be observed as clear crystals deposited on containers or along the surface of the liquid. Slightly soluble in water.

Reactivity Profile

Glycidyl phenyl ether, an ether, can act as a base. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert.

Health Hazard

PGE is a toxic compound exhibiting moderate irritant action and carcinogenicity inanimals. Application of 0.25 mg resulted insevere eye irritation in rabbits, while 500 mgcaused moderate skin irritation over a periodof 24 hours. Prolonged or repeated contactcan cause moderate irritation and skin sensitization in humans.
The symptoms of its toxicity in animalswere depression of the central nervous system and paralysis of the respiratory tract.Prolonged exposure caused changes in thekidney, liver, thymus, and testes, and lossof hair in rats. The toxicity of this compound in humans is low and the health hazardcan arise primarily from its skin-sensitizationaction.
LD50 value, oral (mice): 1400 mg/kg
DGE showed carcinogenicity in rats, causingnasal cancer.

Fire Hazard

Glycidyl phenyl ether is probably combustible.

Contact allergens

This monoglycidyl derivative is a reactive diluent in epoxy resins Bisphenol A type. It is a component of epoxy paints, epoxy glues, and epoxy resins. Sensitization has been observed in many professions, such as in construction workers, marble workers, ceramic workers, and shoemakers.

Safety Profile

Confirmed carcinogen with experimental carcinogenic data. Moderately toxic by ingestion, skin contact, and subcutaneous routes. A severe eye and skin irritant. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. Used as a chemical intermediate. See also ETHERS

Potential Exposure

PGE is used to increase storage time and stability of halogenated compounds; as a reactive diluent in uncured epoxy resins to reduce the viscosity of the uncured system for ease in casting; adhesive, and laminating applications. NIOSH once estimated that 8000 workers are potentially exposed to PGE.

Carcinogenicity

Chronic exposure of rats to 1 or 12ppm 6 hours/day, 5 days/week for 2 years caused an increased incidence of rhinitis, squamous metaplasia, and epidermal carcinomas of the nasal cavity.4 The IARC has determined that there is sufficient evidence for the carcinogenicity of PGE in animals and that it is possibly carcinogenic to humans.

Shipping

UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, amines, and curing agents. PGE can presumably form explosive peroxides

Waste Disposal

Concentrated waste containing no peroxides-discharge liquid at a controlled rate near a pilot flame. Concentrated waste containing peroxidesperforation of a container of the waste from a safe distance followed by open burning.

Properties of Glycidyl phenyl ether

Melting point: 3.5 °C(lit.)
Boiling point: 245-247 °C(lit.)
Density  1.109 g/mL at 25 °C(lit.)
vapor density  5.2 (vs air)
vapor pressure  0.03 mm Hg ( 20 °C)
refractive index  n20/D 1.531
Flash point: >230 °F
storage temp.  Store below +30°C.
solubility  2.4g/l
form  Liquid
color  Clear colorless to yellow
Water Solubility  2.4 g/L (20 ºC)
BRN  2744
Exposure limits TLV-TWA 6 mg/m3 (1 ppm) (ACGIH); 1 ppm (15 min) (NIOSH).
Stability: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference 122-60-1(CAS DataBase Reference)
NIST Chemistry Reference Oxirane, (phenoxymethyl)-(122-60-1)
IARC 2B (Vol. 47, 71) 1999
EPA Substance Registry System Phenyl glycidyl ether (122-60-1)

Safety information for Glycidyl phenyl ether

Signal word Danger
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H315:Skin corrosion/irritation
H317:Sensitisation, Skin
H332:Acute toxicity,inhalation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
H341:Germ cell mutagenicity
H350:Carcinogenicity
H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P202:Do not handle until all safety precautions have been read and understood.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for Glycidyl phenyl ether

InChIKey FQYUMYWMJTYZTK-UHFFFAOYSA-N

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