Chemical Book India PDF
Chemical Safety Data Sheet MSDS / SDS

2,3-epoxypropyl phenyl ether SDS

Revision Date:2024-04-25 Revision Number:1
Section 1 Section 2 Section 3 Section 4 Section 5 Section 6 Section 7 Section 8 Section 9 Section 10 Section 11 Section 12 Section 13 Section 14 Section 15 Section 16

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

  • Product name: 2,3-epoxypropyl phenyl ether
  • CAS: 122-60-1

Relevant identified uses of the substance or mixture and uses advised against

  • Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
  • Uses advised against: none

Company Identification

  • Company:Chemicalbook.in
  • Address:5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
  • Telephone:+91 9550333722

SECTION 2: Hazards identification

Classification of the substance or mixture

Skin irritation, Category 2

Skin sensitization, Category 1

Acute toxicity - Category 4, Inhalation

Specific target organ toxicity – single exposure, Category 3

Germ cell mutagenicity, Category 2

Carcinogenicity, Category 1B

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

GHS label elements, including precautionary statements

  • Pictogram(s)
  • Signal word Danger
Hazard statement(s)

H315 Causes skin irritation

H317 May cause an allergic skin reaction

H332 Harmful if inhaled

H335 May cause respiratory irritation

H341 Suspected of causing genetic defects

H350 May cause cancer

H412 Harmful to aquatic life with long lasting effects

Precautionary statement(s)
Prevention

P264 Wash ... thoroughly after handling.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P272 Contaminated work clothing should not be allowed out of the workplace.

P271 Use only outdoors or in a well-ventilated area.

P203 Obtain, read and follow all safety instructions before use.

P273 Avoid release to the environment.

Response

P302+P352 IF ON SKIN: Wash with plenty of water/...

P321 Specific treatment (see ... on this label).

P332+P317 If skin irritation occurs: Get medical help.

P362+P364 Take off contaminated clothing and wash it before reuse.

P333+P317 If skin irritation or rash occurs: Get medical help.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P317 Get medical help.

P319 Get medical help if you feel unwell.

P318 IF exposed or concerned, get medical advice.

Storage

P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.

Disposal

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

SECTION 3: Composition/information on ingredients

Substance

  • Chemical name: 2,3-epoxypropyl phenyl ether
  • Common names and synonyms: 2,3-epoxypropyl phenyl ether
  • CAS number: 122-60-1
  • EC number: 204-557-2
  • Concentration: 100%

SECTION 4: First aid measures

Description of necessary first-aid measures

If inhaled

Fresh air, rest.

Following skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap.

Following eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Following ingestion

Rinse mouth.

Most important symptoms/effects, acute and delayed

Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Symptoms: Irritation eyes, skin; upper respiratory system; skin sensitization; narcosis; possible hematopoietic, reproductive effects; [potential occupational carcinogen] Target Organs: Eyes, skin, central nervous system, hematopoietic system, reproductive system (NIOSH, 2016)

Indication of immediate medical attention and special treatment needed, if necessary

Absorption, Distribution and Excretion

Phenyl glycidyl ether percutaneous absorption rates were 13.5 mg/sq cm/hr in rats & 4.2 mg/sq cm/hr for rabbits.

SECTION 5: Firefighting measures

Suitable extinguishing media

Dry chemical, carbon dioxide, or alcohol foam.

Specific hazards arising from the chemical

This chemical is probably combustible. (NTP, 1992)

Special protective actions for fire-fighters

Use water spray, foam, powder, carbon dioxide.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in covered containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Environmental precautions

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in covered containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Methods and materials for containment and cleaning up

Do NOT let this chemical enter the environment. Collect leaking liquid in covered containers. Absorb remaining liquid in sand or inert absorbent and remove to safe place.

SECTION 7: Handling and storage

Precautions for safe handling

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store in an area without drain or sewer access. Separated from strong oxidants, strong bases, strong acids and amines. Cool. Keep in the dark.Store in an area without drain or sewer access. Seperated from strong oxidants, strong bases, strong acids and amines. Cool. Keep in the dark.

SECTION 8: Exposure controls/personal protection

Control parameters

Occupational Exposure limit values

TLV: 0.1 ppm as TWA; (skin); (SEN); A3 (confirmed animal carcinogen with unknown relevance to humans).MAK: skin absorption (H); sensitization of skin (SH); carcinogen category: 2

Biological limit values

no data available

Appropriate engineering controls

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Wear safety goggles or eye protection in combination with breathing protection.

Skin protection

Protective gloves. Protective clothing.

Respiratory protection

Use ventilation, local exhaust or breathing protection.

Thermal hazards

no data available

SECTION 9: Physical and chemical properties and safety characteristics

  • Physical state:

    Liquid.

  • Colour:

    Colorless.

  • Odour:

    no data available

  • Melting point/freezing point:

    3.5 °C.

  • Boiling point or initial boiling point and boiling range:

    245 °C.

  • Flammability:

    Class IIIB Combustible Liquid: Fl.P. at or above 200°F.

  • Lower and upper explosion limit/flammability limit:

    Combustible

  • Flash point:

    120 °C.

  • Auto-ignition temperature:

    430 °C.

  • Decomposition temperature:

    no data available

  • pH:

    no data available

  • Kinematic viscosity:

    no data available

  • Solubility:

    1 to 5 mg/mL at 64° F (NTP, 1992)

  • Partition coefficient n-octanol/water:

    log Pow = 1.61. Temperature:25 °C.

  • Vapour pressure:

    0.013 hPa. Temperature:25 °C.

  • Density and/or relative density:

    1.111. Temperature:21 °C.

  • Relative vapour density:

    5.2 (vs air)

  • Particle characteristics:

    no data available

SECTION 10: Stability and reactivity

Reactivity

100 ppm; NIOSH considers phenyl glycidyl ether to be a potential occupational carcinogen.

The substance can presumably form explosive peroxides. The substance polymerizes under the influence of acids, bases and amines. Reacts violently with strong oxidants. This generates fire and explosion hazard.

Chemical stability

no data available

Possibility of hazardous reactions

PHENYL GLYCIDYL ETHER, an ether, can act as a base. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert.

Conditions to avoid

no data available

Incompatible materials

Incompatibilities: Contact with strong oxidizing agents may cause fires and explosions. Contact with amines, strong acids, and strong bases may cause polymerization with the liberation of heat and spattering. Exposure to light and air may result in the formation of explosive peroxides.

Hazardous decomposition products

Energy of decomposition (in range 360-450 deg C) measured as 0.626 kJ/g.

SECTION 11: Toxicological information

Acute toxicity

  • Oral: LD50 - rat - 4 260 mg/kg bw.
  • Inhalation: LC100 - rat (male) - 323 ppm.
  • Dermal: LD50 - rabbit (male) - 1 666 mg/kg bw.

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

Evaluation: No epidemiological data relevant to the carcinogenicity of phenyl glycidyl ether were available. There is sufficient evidence in experimental animals for the carcinogenicity of phenyl glycidyl ether. Overall evaluation: Phenyl glycidyl ether is possibly carcinogenic to humans (Group 2B).

Reproductive toxicity

no data available

STOT-single exposure

The substance is irritating to the eyes, skin and respiratory tract.

STOT-repeated exposure

Repeated or prolonged contact may cause skin sensitization. This substance is possibly carcinogenic to humans.

Aspiration hazard

A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster.

SECTION 12: Ecological information

Toxicity

  • Toxicity to fish: LC50 - Carassius auratus - 43 mg/L - 96 h.
  • Toxicity to daphnia and other aquatic invertebrates: no data available
  • Toxicity to algae: no data available
  • Toxicity to microorganisms: no data available

Persistence and degradability

AEROBIC: A 5-day theoretical BOD of 6% was measured for phenyl glycidyl ether using a standard dilution method and an effluent from a biological sanitary waste treatment plant as the inoculum(1). A 5-day theoretical BOD of 0% was measured using a BOD dilution method and an acclimated sewage inoculum(2). Phenyl glycidyl ether, present at 100 mg/L, reached 33% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L and the Japanese MITI test(3).

Bioaccumulative potential

An estimated BCF of 8 was calculated for phenyl glycidyl ether(SRC), using a water solubility of 2,400 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Mobility in soil

The Koc of phenyl glycidyl ether is estimated as 60(SRC), using a water solubility of 2,400 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that phenyl glycidyl ether is expected to have high mobility in soil.

Other adverse effects

no data available

SECTION 13: Disposal considerations

Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

SECTION 14: Transport information

UN Number

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

UN Proper Shipping Name

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

Transport hazard class(es)

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

Packing group, if applicable

ADR/RID: Not dangerous goods. (For reference only, please check.)

IMDG: Not dangerous goods. (For reference only, please check.)

IATA: Not dangerous goods. (For reference only, please check.)

Environmental hazards

ADR/RID: No

IMDG: No

IATA: No

Special precautions for user

no data available

Transport in bulk according to IMO instruments

no data available

SECTION 15: Regulatory information

Safety, health and environmental regulations specific for the product in question

European Inventory of Existing Commercial Chemical Substances (EINECS)
Listed.
EC Inventory
Listed.
United States Toxic Substances Control Act (TSCA) Inventory
Listed.
China Catalog of Hazardous chemicals 2015
Listed.
New Zealand Inventory of Chemicals (NZIoC)
Listed.
(PICCS)
Listed.
Vietnam National Chemical Inventory
Listed.
IECSC)
Listed.
Korea Existing Chemicals List (KECL)
Listed.

SECTION 16: Other information

Abbreviations and acronyms

  • CAS: Chemical Abstracts Service
  • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
  • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
  • IMDG: International Maritime Dangerous Goods
  • IATA: International Air Transportation Association
  • TWA: Time Weighted Average
  • STEL: Short term exposure limit
  • LC50: Lethal Concentration 50%
  • LD50: Lethal Dose 50%
  • EC50: Effective Concentration 50%

References

  • IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
  • HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
  • IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
  • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
  • CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
  • ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
  • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
  • Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
  • ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

Do NOT take working clothes home.Check for peroxides prior to distillation; eliminate if found.

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any