Fotemustine
Synonym(s):(+-)-Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate;Muphoran;Mustophorane;P-[1-[[[(2-Chloroethyl)nitrosoamino]carbonyl]amino]ethyl]-phosphonic acid diethyl ester;S 10036
- CAS NO.:92118-27-9
- Empirical Formula: C9H19ClN3O5P
- Molecular Weight: 315.69
- MDL number: MFCD00866278
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:43
![Fotemustine Structural](https://img.chemicalbook.in/CAS/GIF/92118-27-9.gif)
What is Fotemustine?
Description
Fotemustine is a new nitrosourea reportedly effective in the treatment of disseminated malignant melanoma, with only mild hematological toxicity. Response rate is generally lower in patients with colonic, breast, head and neck cancer.
Originator
Servier (France)
The Uses of Fotemustine
Fotemustine is used in patients malignant gliomas to improve the efficacy of radiotherapy. Used in the treatment of glioblastomas.
What are the applications of Application
Fotemustene is a nitrosourea alkylating agent
Definition
ChEBI: Diethyl (1-{[(2-chloroethyl)(nitroso)carbamoyl]amino}ethyl)phosphonate is a member of the class of N-nitrosoureas that is ethyl diethylphosphonate in the hydrogen at position 1 of the ethyl group attached to the phosphorus has been replaced by a [(2-chloroethyl)(nitroso)carbamoyl]amino group. It is an organic phosphonate, a member of N-nitrosoureas and an organochlorine compound.
brand name
Muphoran
Properties of Fotemustine
Melting point: | 85° |
Density | 1.37±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | H2O: ≥1mg/mL |
form | powder |
pka | 9.47±0.46(Predicted) |
color | light yellow |
CAS DataBase Reference | 92118-27-9(CAS DataBase Reference) |
Safety information for Fotemustine
Signal word | Warning |
Pictogram(s) |
![]() Health Hazard GHS08 |
GHS Hazard Statements |
H351:Carcinogenicity |
Precautionary Statement Codes |
P281:Use personal protective equipment as required. |
Computed Descriptors for Fotemustine
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1-Bromo-3,5-Di-Tert-Butylbenzene S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
![Tris(2-chloroethyl) phosphate](https://img.chemicalbook.in/CAS/GIF/115-96-8.gif)
![Ethyl dichlorophosphate](https://img.chemicalbook.in/CAS/GIF/1498-51-7.gif)
![Bendamustine](https://img.chemicalbook.in/CAS/GIF/97832-05-8.gif)
![Triethyl phosphate](https://img.chemicalbook.in/CAS/GIF/78-40-0.gif)
![DIETHYL ETHYLPHOSPHONATE](https://img.chemicalbook.in/CAS/GIF/78-38-6.gif)
![Diethyl phosphite](https://img.chemicalbook.in/CAS/GIF/762-04-9.gif)
![Bendamustine hydrochloride](https://img.chemicalbook.in/CAS/GIF/3543-75-7.gif)
![Triethyl phosphite](https://img.chemicalbook.in/CAS/GIF/122-52-1.gif)
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