Ethyl dichlorophosphate
Synonym(s):Ethyl phosphorodichloridate
- CAS NO.:1498-51-7
- Empirical Formula: C2H5Cl2O2P
- Molecular Weight: 162.94
- MDL number: MFCD00002069
- EINECS: 216-099-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-07-26 18:47:09
What is Ethyl dichlorophosphate?
Chemical properties
Light Yellow Liquid
The Uses of Ethyl dichlorophosphate
Ethyl Dichlorophosphate is an intermediate used in the synthesis of b-D-2'-deoxy-2'-a-fluoro-2'-b-C-methyluridine nucleotide prodrug (PSI-7977) for treatment of hepatitis C virus. It is also used to prepare dialkylphosphocholines with antiprotozoal, antifungal and antitumor activities.
General Description
Ethyl dichlorophosphate is strongly irritating to skin. Ethyl dichlorophosphate may cause visible destruction or irreversible alterations in human skin tissue at the site of contact. Ethyl dichlorophosphate is very toxic by ingestion, inhalation, or by skin absorption. Ethyl dichlorophosphate may be combustible though Ethyl dichlorophosphate may require some effort to ignite.
Air & Water Reactions
Reacts with water to form hydrogen chloride(hydrochloric acid)
Reactivity Profile
Organophosphates, such as Ethyl dichlorophosphate, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Health Hazard
Inhalation of vapor irritates nose and throat. Contact with liquid causes severe burns of eyes and skin. Ingestion causes severe burns of mouth and stomach.
Safety Profile
A corrosive material that is very toxic to tissue. A severe eye, skin, and mucous membrane irritant. When heated to decomposition it emits very toxic fumes of Cland POx.
Properties of Ethyl dichlorophosphate
Melting point: | -42.5 °C |
Boiling point: | 60-65 °C10 mm Hg(lit.) |
Density | 1.373 g/mL at 25 °C(lit.) |
refractive index | n |
Flash point: | >230 °F |
storage temp. | Inert atmosphere,Room Temperature |
form | Liquid |
color | Clear colorless to pale brown |
CAS DataBase Reference | 1498-51-7(CAS DataBase Reference) |
NIST Chemistry Reference | Ethyl dichlorophosphate(1498-51-7) |
EPA Substance Registry System | Ethyl dichlorophosphate (1498-51-7) |
Safety information for Ethyl dichlorophosphate
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral H314:Skin corrosion/irritation H330:Acute toxicity,inhalation |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Ethyl dichlorophosphate
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