FMoc-Val-Cit-PAB-PNP
- CAS NO.：863971-53-3
- Empirical Formula: C40H42N6O10
- Molecular Weight: 766.8
- MDL number: MFCD22200278
- Update Date: 2024-11-19 23:02:33
What is FMoc-Val-Cit-PAB-PNP?
Description
Fmoc-Val-Cit-PAB-PNP is a a cleavable ADC linker used in antibody drug conjugate. The Val-Cit linker was designed to be cleaved by cathepsin B. PNP group is a good leaving group when reacting with amine bearing payload.
Biological Activity
Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker that can be used to synthesize antibody drug conjugates (ADCs).
Properties of FMoc-Val-Cit-PAB-PNP
| Melting point: | 189 °C(dec.) |
| Boiling point: | 1024.0±65.0 °C(Predicted) |
| Density | 1.335±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| form | powder to crystal |
| pka | 10.63±0.46(Predicted) |
| color | White to Light yellow |
Safety information for FMoc-Val-Cit-PAB-PNP
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H227:Flammable liquids |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for FMoc-Val-Cit-PAB-PNP
FMoc-Val-Cit-PAB-PNP manufacturer
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