Val-cit-PAB-OH
- CAS NO.：159857-79-1
- Empirical Formula: C18H29N5O4
- Molecular Weight: 379.45
- MDL number: MFCD22381209
- EINECS: 826-617-2
- Update Date: 2024-03-29 16:09:00
What is Val-cit-PAB-OH?
Description
Val-Cit-PAB-OH is a peptide cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Cit will specifically be cleaved by Cathepsin B.
The Uses of Val-cit-PAB-OH
Val-cit-PAB-OH acts as a reagent in the preparation of cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy, preparation of monomethylvaline derivative conjugates with ligands and antibodies for cancer treatment.
Properties of Val-cit-PAB-OH
| Melting point: | 168 °C(dec.) |
| Boiling point: | 715.0±60.0 °C(Predicted) |
| Density | 1.243±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 1 mg/ml |
| form | powder to crystal |
| pka | 13.75±0.46(Predicted) |
| color | White to Almost white |
Safety information for Val-cit-PAB-OH
Computed Descriptors for Val-cit-PAB-OH
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