MC-Val-Cit-PAB
- CAS NO.：159857-80-4
- Empirical Formula: C28H40N6O7
- Molecular Weight: 572.65
- MDL number: MFCD26142966
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-06 10:55:52
What is MC-Val-Cit-PAB?
Description
MC-Val-Cit-PAB-OH is a cleavable peptide linker. The Val-Cit was designed to be cleaved specifically by Cathepsin B. MC group is reactive with thiol moiety
The Uses of MC-Val-Cit-PAB
N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide is used as a reagent to prepare antibody-drug conjugates, which are compounds that selectively deliver cytotoxic drugs to a tumour-associated antigen.
Properties of MC-Val-Cit-PAB
| Boiling point: | 931.6±65.0 °C(Predicted) |
| Density | 1.276 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO: soluble |
| form | powder to crystal |
| pka | 13.41±0.70(Predicted) |
| color | White to Almost white |
| CAS DataBase Reference | 159857-80-4 |
Safety information for MC-Val-Cit-PAB
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for MC-Val-Cit-PAB
| InChIKey | UMDCMQHPXQLHGR-OFVILXPXSA-N |
| SMILES | C(N)(=O)[C@H](CCCNC(N)=O)N(C(=O)[C@H](C(C)C)NC(=O)CCCCCN1C(=O)C=CC1=O)C1=CC=C(CO)C=C1 |
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![L-Ornithine, N5-(aMinocarbonyl)-N2-[N-[(9H-fluoren-9-ylMethoxy)carbonyl]-L-valyl]-](https://img.chemicalbook.in/CAS/20150408/GIF/159858-21-6.gif)
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