Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listFluorochloridone

Fluorochloridone

  • CAS NO.:61213-25-0
  • Empirical Formula: C12H10Cl2F3NO
  • Molecular Weight: 312.12
  • MDL number: MFCD00144317
  • EINECS: 262-661-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-06 19:41:26
Fluorochloridone Structural

What is Fluorochloridone?

Chemical properties

Brown solid. Easily soluble in acetone, chlorobenzene, ethanol, xylene and other organic solvents, with a solubility of 100-150g/L. Solubility in kerosene <5g/L. The solubility in water is 28mg/L. Partition coefficient (n-octanol/water) 2300 (20°C). The half-life is 7d at 60°C and pH 4, 18d at 60°C and pH 7, and the half-life in soil is 11-100d.

The Uses of Fluorochloridone

Flurochloridone (FLC) is a monophenyl pyrrolidinone selective herbicide that can be used in herbicidal composition to control weed in crop fields. It is commonly used to inhibit weeds that occur during the growth of crop plants, such as grains, sunflowers, and potatoes.

Definition

ChEBI: Flurochloridone is a member of pyrrolidines, a member of (trifluoromethyl)benzenes and an organochlorine compound. It has a role as a carotenoid biosynthesis inhibitor, an agrochemical and a herbicide.

Synthesis

The synthesis of Fluorochloridone is as follows:To a 1L three-neck flask, N-allyl-N-dichloroacetyl-m-trifluoromethylaniline (31.1 g, 0.1 mol) and 715 ml of 1,2-dichloroethane were added as a solvent, dissolved under stirring, and then added. Cuprous chloride (2.97g, 0.03mol) and 2,2-bipyridyl (4.68g, 0.03mol) were reacted at 80°C for 3 hours, cooled to room temperature, and the reaction solution was filtered through a short silica gel column to give dichloromethane. Elution and desolvation yielded 31.3 g of pyrotropone, a content of 97%, an anti-contrast ratio of ≥3:1, and a yield of 97.6%.61213-25-0.png

Metabolic pathway

From hydrolytic and photolytic studies of flurochloridone in buffer solution, no hydrolysis of flurochloridone occurs at pH 5, 7, or 9 at 25°C or at pH 5 at 40°C. Appreciable hydrolysis occurs at 40°C at pH 7 and 9 with half-lives of 190 and 140 days, respectively. Five hydrolytic degradation products and six photolytic degradation products are identified. The major photolytic degradation product which contains 39% of the radioactivity is 4-(chloromethyl)-3-hydroxy-1-[3- (trifluoromethyl)phenyl]-2-pyrrolidinone with a mixture of cis and trans isomers. The formation of this major degradation product suggests that the major photolytic pathway involves homolytic cleavage of the carbon ? chlorine bond at the 3-position of the pyrrolidinone ring and the free radical intermediate can react with water to give the major product or eliminate the hydrogen radical to form 4- (chloromethyl)-1,5-dihydro-1-[3- (trifluoromethyl)phenyl]pyrrol-2H-one.

Mode of action

Flurochloridone is the active substance of some pre-emergence herbicides. It has an inhibitory effect on the synthesis of carotenoids, which protect chlorophylls against oxidative stress.

Toxicity evaluation

The acute oral LD50 of male rats is 4000 mg/kg, the acute transdermal LD50 of rabbits is >5000 mg/kg, and the acute inhalation of rats is LC50 10.3 mg/L (4h). Slightly irritating to rabbit skin and eyes.

Properties of Fluorochloridone

Melting point: 67.65°C
Boiling point: 212.5 °C
Density  1.3924 (estimate)
Flash point: >100 °C
storage temp.  under inert gas (nitrogen or Argon) at 2-8°C
solubility  DMSO (Slightly), Methanol (Slightly)
form  Solid
pka -3.59±0.60(Predicted)
color  Pale Brown to Light Brown
CAS DataBase Reference 61213-25-0(CAS DataBase Reference)
NIST Chemistry Reference 2-Pyrrolidinone, 3-chloro-4-(chloromethyl)-1-[3-(trifluoromethyl)phenyl]-(61213-25-0)
EPA Substance Registry System Flurochloridone (61213-25-0)

Safety information for Fluorochloridone

Computed Descriptors for Fluorochloridone

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.