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HomeProduct name listEthylene glycol diphenyl ether

Ethylene glycol diphenyl ether

Synonym(s):Ethylene glycol diphenyl ether

  • CAS NO.:104-66-5
  • Empirical Formula: C14H14O2
  • Molecular Weight: 214.26
  • MDL number: MFCD00003039
  • EINECS: 203-224-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-05-29 16:45:47
Ethylene glycol diphenyl ether Structural

What is Ethylene glycol diphenyl ether?

Chemical properties

Off-white Crystals

The Uses of Ethylene glycol diphenyl ether

1,2-Diphenoxyethane is a reagent that is used in the production and use of activatable delivery compounds containing drugs or a detectable moiety and singlet oxygen-labile linkers.

Preparation

The preparation of Ethylene glycol diphenyl ether is as follows:A three-necked flask was charged with 15.7 g of bromobenzene (100 mmol) and 47 ml of DMF, and stirred. 12.7 g of sodium carbonate (120 mmol, 1.2 eq.), 1.9 g of cuprous iodide (10 mmol, 0.1 eq.), 1.87 g of 2,2'-bipyridine (12 mmol, 0.1 eq.) and 7.4 g of ethylene glycol (120 mmol, 1.2 equivalent), the reaction mixture was stirred at 100 ° C overnight. After recovering DMF under reduced pressure, 100 ml of water and 100 ml of toluene were added, and the aqueous phase was extracted three times with 300 ml of toluene, and the organic layers were combined. Washed sequentially with 5% sodium carbonate. The organic phase was dried over anhydrous sodium sulfate, filtered, and then filtered and evaporated,The crude product was recrystallized from isopropanol and dried in vacuo to give 19.5 g of product, yield 91%, purity over 99%.

104-66-5.png

What are the applications of Application

Ethylene glycol diphenyl ether can be used as a new heat-sensitive material sensitizer and a potential polyolefin catalyst additive.

General Description

1,2-Diphenoxyethane is the intermediate formed during sonochemical oxidation of phenoxyacetic acid and chlorophenol.

Flammability and Explosibility

Non flammable

Properties of Ethylene glycol diphenyl ether

Melting point: 94-96 °C (lit.)
Boiling point: 185 °C / 12mmHg
Density  1.0781 (rough estimate)
vapor pressure  0Pa at 25℃
refractive index  1.5570 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  Chloroform (Slightly), Methanol (Slightly)
form  Solid
color  White to Off-White
Water Solubility  22mg/L at 25℃
BRN  2052248
CAS DataBase Reference 104-66-5(CAS DataBase Reference)
EPA Substance Registry System 2-Phenoxyethyl phenyl ether (104-66-5)

Safety information for Ethylene glycol diphenyl ether

Signal word Warning
Pictogram(s)
ghs
Environment
GHS09
GHS Hazard Statements H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P273:Avoid release to the environment.
P391:Collect spillage. Hazardous to the aquatic environment
P501:Dispose of contents/container to..…

Computed Descriptors for Ethylene glycol diphenyl ether

InChIKey XCSGHNKDXGYELG-UHFFFAOYSA-N

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