Etamsylate

Synonym(s):Cyclonamine

CAS NO.：2624-44-4
Empirical Formula: C10H17NO5S
Molecular Weight: 263.31
MDL number: MFCD00867499
EINECS: 220-090-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:08:52

What is Etamsylate?

Chemical properties

White Solid

The Uses of Etamsylate

Hemostatic;prostaglandin synthesis inhibitor

The Uses of Etamsylate

Haemostatic / Anti Coagulant

Definition

ChEBI: Etamsylate is a sulfonic acid derivative and an organosulfur compound.

Mechanism of action

Etamsylate is an antihaemorrhagic and vasoprotective agent. It increases platelet adhesiveness and capillary vascular wall resistance, thereby reducing capillary exudation and blood loss.

Clinical Use

Short-term treatment of blood loss in menorrhagia
Prophylaxis of surgical bleeding (unlicensed)

Side Effects

Significant: Hypotension (parenteral). Rarely, severe hypersensitivity reaction, including anaphylaxis.
Blood and lymphatic system disorders: Parenteral: Rarely, neutropenia, agranulocytosis, thrombocytopenia.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, abdominal pain or discomfort.
General disorders and administration site conditions: Asthenia (parenteral). Rarely, fever.
Musculoskeletal and connective tissue disorders: Rarely, arthralgia.
Nervous system disorders: Headache.
Skin and subcutaneous tissue disorders: Rash.
Vascular disorders: Rarely, thromboembolism (parenteral).

Metabolism

Etamsylate is excreted unchanged, mainly in the urine.

Properties of Etamsylate

Melting point:	125°
Density	1.3441 (rough estimate)
refractive index	1.5060 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Very soluble in water, freely soluble in methanol, soluble in anhydrous ethanol, practically insoluble in methylene chloride.
form	neat
form	Solid
color	White to Pale Red
Merck	14,3722
Stability:	Hygroscopic
InChI	InChI=1S/C6H6O5S.C4H11N/c7-4-1-2-5(8)6(3-4)12(9,10)11;1-3-5-4-2/h1-3,7-8H,(H,9,10,11);5H,3-4H2,1-2H3
CAS DataBase Reference	2624-44-4(CAS DataBase Reference)
EPA Substance Registry System	Ethamsylate (2624-44-4)

Safety information for Etamsylate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P312:Call a POISON CENTER or doctor/physician if you feel unwell. P313:Get medical advice/attention. P362:Take off contaminated clothing and wash before reuse. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..…