EPIMESTROL
- CAS NO.:7004-98-0
- Empirical Formula: C19H26O3
- Molecular Weight: 302.41
- MDL number: MFCD00198991
- EINECS: 230-278-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:41
What is EPIMESTROL?
Originator
Stimovul,Organon,W. Germany,1976
The Uses of EPIMESTROL
Anterior pituitary activator.
Definition
ChEBI: Epimestrol is a steroid. It derives from a hydride of an estrane.
Manufacturing Process
Reduction of 16-keto-17(α)-hydroxyestratrienol-3-methyl to 16,17- dihydroxyestratrienol-3-methyl ether: A solution of 800 mg of the alpha ketol methyl ether in 100 cc of ethanol and 10 cc of acetic acid was carefully maintained at 40°C (water bath), and 200 g of freshly prepared sodium amalgam (2%) were added in small pieces with efficient swirling. Before all ofthe amalgam had been added, a precipitation of sodium acetate occurred, and at this point an additional 100 cc of 50% acetic acid were added. After all the reducing agent had been added, the mixture was transferred to a separatory funnel with ether and water. The mercury plus aqueous phase was separated, after partitioning, from the ether; the latter may be further washed with water, with 0.5N sodium hydroxide, and again with water to purify the alpha glycol. Evaporation of the ethereal phase yielded a crystalline residue of the isomeric transoid (16(β),17(α)-dihydroxy-steroid-3-methyl ether and cisoid 16(α),17(α)dihydroxy-steroid-3-methyl ether.
Therapeutic Function
Anterior pituitary activator
Properties of EPIMESTROL
Melting point: | 158-160° |
alpha | D20 +48° (chloroform) |
Boiling point: | 450.8±45.0 °C(Predicted) |
Density | 1.185±0.06 g/cm3(Predicted) |
pka | 14.53±0.60(Predicted) |
Safety information for EPIMESTROL
Computed Descriptors for EPIMESTROL
New Products
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