Estradiol
Synonym(s):1,3,5(10)-Estratriene-3,17α-diol;3,17α-Dihydroxy-1,3,5(10)-estratriene;Epiestradiol
- CAS NO.:57-91-0
- Empirical Formula: C18H24O2
- Molecular Weight: 272.39
- MDL number: MFCD00064144
- EINECS: 200-354-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is Estradiol?
Chemical properties
White Solid
The Uses of Estradiol
Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.
What are the applications of Application
α-Estradiol is a ligand for ERα and ERβ
Definition
ChEBI: An estradiol that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17 (the 17alpha stereoisomer).
Biological Activity
Endogenous estrogen receptor ligand (K i values are 0.2 and 1.2 nM for ER α and ER β receptors respectively).
Biochem/physiol Actions
Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke.
storage
Room temperature
Purification Methods
17-Estradiol recrystallises from aqueous EtOH (80%) as the hemihydrate and differs from the -anomer (below) by not precipitating with digitonin in 80% aqueous EtOH. The diacetate [1474-52-8] crystallises from aqueous EtOH in needles with m 139-140o. The 3-benzoate crystallises in three forms m 158o, 153o and 63o.
Properties of Estradiol
Melting point: | 176-180 °C(lit.) |
Boiling point: | 355.44°C (rough estimate) |
alpha | D20 +53 to +56° (c = 0.9 in dioxane) |
Density | 1.0708 (rough estimate) |
refractive index | 1.4800 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | ethanol: 50 mg/mL, clear, colorless |
form | powder |
pka | 10.27±0.60(Predicted) |
color | white with slight yellow |
Water Solubility | 3.9mg/L(25 ºC) |
Merck | 14,3704 |
CAS DataBase Reference | 57-91-0(CAS DataBase Reference) |
NIST Chemistry Reference | Estra-1,3,5(10)-triene-3,17alpha-diol(57-91-0) |
EPA Substance Registry System | Estra-1,3,5(10)-triene-3,17-diol, (17.alpha.)- (57-91-0) |
Safety information for Estradiol
Signal word | Danger |
Pictogram(s) |
Health Hazard GHS08 Environment GHS09 |
GHS Hazard Statements |
H341:Germ cell mutagenicity H351:Carcinogenicity H362:Reproductive toxicity, effects on or via lactation H410:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P263:Avoid contact during pregnancy/while nursing. P273:Avoid release to the environment. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for Estradiol
Abamectin manufacturer
Allmpus Laboratories Pvt Ltd
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