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HomeProduct name listEstradiol

Estradiol

Synonym(s):1,3,5(10)-Estratriene-3,17α-diol;3,17α-Dihydroxy-1,3,5(10)-estratriene;Epiestradiol

  • CAS NO.:57-91-0
  • Empirical Formula: C18H24O2
  • Molecular Weight: 272.39
  • MDL number: MFCD00064144
  • EINECS: 200-354-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 19:05:58
Estradiol Structural

What is Estradiol?

Chemical properties

White Solid

The Uses of Estradiol

Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.

What are the applications of Application

α-Estradiol is a ligand for ERα and ERβ

Definition

ChEBI: An estradiol that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17 (the 17alpha stereoisomer).

Biological Activity

Endogenous estrogen receptor ligand (K i values are 0.2 and 1.2 nM for ER α and ER β receptors respectively).

Biochem/physiol Actions

Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke.

storage

Room temperature

Purification Methods

17-Estradiol recrystallises from aqueous EtOH (80%) as the hemihydrate and differs from the -anomer (below) by not precipitating with digitonin in 80% aqueous EtOH. The diacetate [1474-52-8] crystallises from aqueous EtOH in needles with m 139-140o. The 3-benzoate crystallises in three forms m 158o, 153o and 63o.

Properties of Estradiol

Melting point: 176-180 °C(lit.)
Boiling point: 355.44°C (rough estimate)
alpha  D20 +53 to +56° (c = 0.9 in dioxane)
Density  1.0708 (rough estimate)
refractive index  1.4800 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  ethanol: 50 mg/mL, clear, colorless
form  powder
pka 10.27±0.60(Predicted)
color  white with slight yellow
Water Solubility  3.9mg/L(25 ºC)
Merck  14,3704
CAS DataBase Reference 57-91-0(CAS DataBase Reference)
NIST Chemistry Reference Estra-1,3,5(10)-triene-3,17alpha-diol(57-91-0)
EPA Substance Registry System Estra-1,3,5(10)-triene-3,17-diol, (17.alpha.)- (57-91-0)

Safety information for Estradiol

Signal word Danger
Pictogram(s)
ghs
Health Hazard
GHS08
ghs
Environment
GHS09
GHS Hazard Statements H341:Germ cell mutagenicity
H351:Carcinogenicity
H362:Reproductive toxicity, effects on or via lactation
H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P263:Avoid contact during pregnancy/while nursing.
P273:Avoid release to the environment.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for Estradiol

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