Eflornithine hydrochloride hydrate
Synonym(s):DFMO, Eflornithine, RMI-71782;DL-α-Difluoromethylornithine, Hydrochloride - CAS 96020-91-6 - Calbiochem
- CAS NO.:96020-91-6
- Empirical Formula: C6H15ClF2N2O3
- Molecular Weight: 236.64
- MDL number: MFCD00242734
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-06 15:28:16
What is Eflornithine hydrochloride hydrate?
Description
Difluoromethylornithine HCl (96020-91-6) is a selective inhibitor of ornithine decarboxylase.1?Induces apoptosis in a variety of cells.2?Difluoromethylornithine HCl displays cancer chemopreventive activity.3?Cell permeable. Active in vivo.
Chemical properties
White Solid
The Uses of Eflornithine hydrochloride hydrate
Eflornithine hydrochloride hydrate is irreversible inhibitor of ornithine decarboxylase, an enzyme involved in polyamine biosynthesis. Antineoplastic; antipneumocystic; antiprotozoal (Trypanosoma). Used in the treatment of hirsutism.
Definition
ChEBI: Eflornithine hydrochloride monohydrate is the hydrochloride and hydrate of the trypanocidal drug eflornithine. It is a hydrochloride and a hydrate. It contains an eflornithine.
brand name
Ornidyl (Sanofi Aventis); Vaniqa (Skinmedica).
General Description
A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Inhibits B16 melanoma-induced angiogenesis in ovo and proliferation of vascular endothelial cells in vitro.
Biochem/physiol Actions
Primary TargetODC
References
1) Verma et al. (1990), Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase; Basic Life Sci., 52 195 2) Takahashi et al. (2000), Alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model; Int. J. Cancer, 85 243 3) Meyskens et al. (1999), Development of difluoromethylornithine (DFMO) as a chemoprevention agent; Clin. Cancer Res., 5 945
Properties of Eflornithine hydrochloride hydrate
Melting point: | >210°C (dec.) |
storage temp. | Inert atmosphere,2-8°C |
solubility | Soluble in Water (up to 25 mg/ml). |
form | White powder |
color | White |
Merck | 14,3522 |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months. |
CAS DataBase Reference | 96020-91-6 |
Safety information for Eflornithine hydrochloride hydrate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Eflornithine hydrochloride hydrate
Abamectin manufacturer
Rivashaa Agrotech Biopharma Pvt. Ltd.
Ralington Pharma
Rusan Pharma Ltd
AKASH PHARMA EXPORTS
SETV ASRV LLP
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