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HomeProduct name listEflornithine hydrochloride hydrate

Eflornithine hydrochloride hydrate

Synonym(s):DFMO, Eflornithine, RMI-71782;DL-α-Difluoromethylornithine, Hydrochloride - CAS 96020-91-6 - Calbiochem

Eflornithine hydrochloride hydrate Structural

What is Eflornithine hydrochloride hydrate?

Description

Difluoromethylornithine HCl (96020-91-6) is a selective inhibitor of ornithine decarboxylase.1?Induces apoptosis in a variety of cells.2?Difluoromethylornithine HCl displays cancer chemopreventive activity.3?Cell permeable. Active in vivo.

Chemical properties

White Solid

The Uses of Eflornithine hydrochloride hydrate

Eflornithine hydrochloride hydrate is irreversible inhibitor of ornithine decarboxylase, an enzyme involved in polyamine biosynthesis. Antineoplastic; antipneumocystic; antiprotozoal (Trypanosoma). Used in the treatment of hirsutism.

Definition

ChEBI: Eflornithine hydrochloride monohydrate is the hydrochloride and hydrate of the trypanocidal drug eflornithine. It is a hydrochloride and a hydrate. It contains an eflornithine.

brand name

Ornidyl (Sanofi Aventis); Vaniqa (Skinmedica).

General Description

A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Inhibits B16 melanoma-induced angiogenesis in ovo and proliferation of vascular endothelial cells in vitro.

Biochem/physiol Actions

Primary TargetODC

References

1) Verma et al. (1990), Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase; Basic Life Sci., 52 195 2) Takahashi et al. (2000), Alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model; Int. J. Cancer, 85 243 3) Meyskens et al. (1999), Development of difluoromethylornithine (DFMO) as a chemoprevention agent; Clin. Cancer Res., 5 945

Properties of Eflornithine hydrochloride hydrate

Melting point: >210°C (dec.)
storage temp.  Inert atmosphere,2-8°C
solubility  Soluble in Water (up to 25 mg/ml).
form  White powder
color  White
Merck  14,3522
Stability: Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
CAS DataBase Reference 96020-91-6

Safety information for Eflornithine hydrochloride hydrate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Eflornithine hydrochloride hydrate

Abamectin manufacturer

Rivashaa Agrotech Biopharma Pvt. Ltd.

1Y
Phone:+91-7926462688
product: Eflornithine hydrochloride monohydrate 98%
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Ralington Pharma

1Y
Phone:+91-9687771722
Whatsapp: +91- 9687771722
product: Eflornithine hydrochloride monohydrate 96020-91-6 98%
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Rusan Pharma Ltd

1Y
Phone:+91-9690022465
Whatsapp: +91-9690022465
product: 96020-91-6 Eflornithine hydrochloride monohydrate 98%
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Micron Pharmaceuticals

1Y
Phone:+91-2224969511
product: 96020-91-6 99%
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AKASH PHARMA EXPORTS

1Y
Phone:+91-9846039283
Whatsapp: +91- 9846039283
product: Eflornithine Hydrochloride Hydrate 99%
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SETV ASRV LLP

1Y
Phone:+91-9731133411
Whatsapp: +91- 9731133411
product: EFLORNITHINE HCL MONOHYDRATE 96020-91-6 95-99%
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DM Pharma

Tamil Nadu
product: Eflornithine hydrochloride monohydrate
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