DL-ETHIONINE

Synonym(s):DL-2-Amino-4-(ethylthio)butyric acid

CAS NO.：67-21-0
Empirical Formula: C6H13NO2S
Molecular Weight: 163.24
MDL number: MFCD00063102
EINECS: 200-647-0
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is DL-ETHIONINE?

Chemical properties

Off-White Solid

The Uses of DL-ETHIONINE

DL-Ethionine is used as a dietary supplement to accelerate cholangiocarcinogenesis in vivo. It is also used to induce oxidative stress in liver to study the levels and activities of anti-oxidative enzymes and compounds such as glutathione.

The Uses of DL-ETHIONINE

antineoplastic; inhibitor DNA methylation

What are the applications of Application

D,L-Ethionine is a racemic mixture of the anti-methylation agent L-Ethionine and its enantiomer D-Ethionine

Definition

ChEBI: A non-proteinogenic alpha-amino acid that is methionine in which the S-methyl group is replaced by an S-ethyl group.

General Description

White crystalline flakes.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

A synthetic thio-substituted amino acid.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition DL-ETHIONINE emits toxic fumes of NOx and SOx.

Fire Hazard

Flash point data for DL-ETHIONINE are not available; however, DL-ETHIONINE is probably combustible.

Biochem/physiol Actions

DL-Ethionine is a racemic mixture of the anti-methylation agent L-Ethionine and its enantiomer D-Ethionine. DL-Ethionine is used as a dietary supplement to accelerate cholangiocarcinogenesis in vivo. DL-Ethionine is used to induce oxidative stress in liver to study the levels and activities of anti-oxidative enzymes and compounds such as glutathione.

Safety Profile

Mddly toxic by ingestion and intraperitoneal routes. Suspected carcinogen with experimental carcinogenic and tumorigenic data. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of SOx and NOx.

Properties of DL-ETHIONINE

Melting point:	265-268 °C
Boiling point:	310℃
alpha	[α]D20 0±0.5° (c=5, dil. HCl)
Density	1.164
refractive index	1.5500 (estimate)
Flash point:	142℃
storage temp.	-20°C
solubility	Methanol (Slightly, Heated), Water (Slightly)
pka	2.23±0.10(Predicted)
form	Crystalline Powder or Flakes
color	White to off-white
Water Solubility	Soluble in water.
Merck	14,3738
BRN	1722529
CAS DataBase Reference	67-21-0(CAS DataBase Reference)
EPA Substance Registry System	S-Ethylhomocysteine (67-21-0)

Safety information for DL-ETHIONINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.