L-ETHIONINE

Synonym(s):L-2-Amino-4-(ethylthio)butyric acid

CAS NO.：13073-35-3
Empirical Formula: C6H13NO2S
Molecular Weight: 163.24
MDL number: MFCD00002626
EINECS: 235-966-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-31 15:41:55

What is L-ETHIONINE?

Chemical properties

White Solid

The Uses of L-ETHIONINE

Ethionine-induced inhibition of protein synthesis and lowering of ATP level in the liver.

Definition

ChEBI: An S-ethylhomocysteine that has S-configuration at the chiral centre.

Purification Methods

Likely impurities are N-acetyl-(R and S)-ethionine, S-methionine, and R-ethionine. Crystallise it from water by adding 4volumes of EtOH or 85% aqueous EtOH. It sublimes at 196-216o/0.3mm with 99.1% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Weiss & Stekol J Am Chem Soc 73 2399 1951, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2658, 2659 1961, Beilstein 4 IV 3194.]

Properties of L-ETHIONINE

Melting point:	280 °C (dec.)(lit.)
alpha	D24 +25.1°; D23 +20.1° (1N HCl) (Armstrong, Lewis)
Density	1.085 (estimate)
refractive index	22 ° (C=1, 1mol/L HCl)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	Aqueous Acid (Slightly), Water (Slightly)
form	solid
Boiling point:	310.4±37.0 °C(Predicted)
pka	2.23±0.10(Predicted)
color	White to Off-White
Merck	14,3738
CAS DataBase Reference	13073-35-3(CAS DataBase Reference)
EPA Substance Registry System	L-Ethionine (13073-35-3)

Safety information for L-ETHIONINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.