DIPERODON HYDROCHLORIDE
Synonym(s):3-(1-Piperidinyl)-1,2-propanediol bis(phenylcarbamate)
- CAS NO.:537-12-2
- Empirical Formula: C22H28ClN3O4
- Molecular Weight: 433.93
- MDL number: MFCD00083307
- EINECS: 208-659-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is DIPERODON HYDROCHLORIDE?
Originator
Diothane Hydrochloride,HMR
The Uses of DIPERODON HYDROCHLORIDE
Diperodon Hydrochloride is an inhibitor of ebola virus (EBOV) and marburg virus (MARV) by an antiviral activity of the G protein-coupled receptor (GPCR) antagonist.
The Uses of DIPERODON HYDROCHLORIDE
analgesic, antipyretic, antiinflammatory
Manufacturing Process
15.0 g phenylisocyanate in 100 ml of anhydrous ether are added to 10 g of N- (1,2-dihydroxypropyl)-piperidine (prepared from glycide and piperidine) and the solution boiled for two hours, after which it is cooled and saturated with dry hydrogen chloride gas. The ether layer is then decanted off and the remaining insoluble product is dissolved in a hot mixture of acetone and ethyl acetate which on cooling precipitates white crystals of the hydrochloride of the ester of 1,2-propanediol, 3-(1-piperidinyl)-, bis(phenylcarbamate); MP 197°- 198°C. A base form may be prepared by adding an equivalent of triethyl amine.
Therapeutic Function
1,2-Propanediol, 3-(1-piperidinyl)-, bis(phenylcarbamate) (ester), hydrochloride
Properties of DIPERODON HYDROCHLORIDE
Melting point: | 193-201°C |
storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
solubility | Methanol (Slightly) |
form | neat |
form | Solid |
color | White |
Safety information for DIPERODON HYDROCHLORIDE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for DIPERODON HYDROCHLORIDE
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