Donepezil Hydrochloride
Synonym(s):(±)-2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-1-indanone hydrochloride;1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride;2,3-Dihydro-5,6-dimethoxy-2-{[1-(phenylmethyl)-4-piperidinyl]methyl}-1H-inden-1-one;Donepezil hydrochloride;E2020
- CAS NO.：120011-70-3
- Empirical Formula: C24H30ClNO3
- Molecular Weight: 415.95
- MDL number: MFCD00881312
- EINECS: 620-543-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-23 16:18:34
What is Donepezil Hydrochloride?
The Uses of Donepezil Hydrochloride
Donepezil hydrochloride is an inhibitor of acetylcholinesterase with a labelled nootropic. It has been used in dose-response experiment to study its efficacy in ameliorating nicotine withdrawal-induced deficits in contextual conditioning in mice. It has also been intraperitoneally injected into rats to study its ability to improve social behavioral deficits, repetitive behavior and hyperactivity. Labeled Donepezil, intended for use as an internal standard for the quantification of Donepezilby GC- or LC-mass spectrometry.
What are the applications of Application
Donepezil hydrochloride is a noncompetitive acetylcholinesterase (AChE) inhibitor
Properties of Donepezil Hydrochloride
| Melting point: | 220-222°C |
| storage temp. | room temp |
| Water Solubility | Soluble in water |
| solubility | insoluble in EtOH; insoluble in DMSO; ≥10.4 mg/mL in H2O |
| form | powder |
| color | white to off-white |
Safety information for Donepezil Hydrochloride
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H300:Acute toxicity,oral H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Donepezil Hydrochloride
| InChIKey | XWAIAVWHZJNZQQ-UHFFFAOYSA-N |
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