DIMETHYLZINC
- CAS NO.:544-97-8
- Empirical Formula: C2H6Zn
- Molecular Weight: 95.46
- MDL number: MFCD00014854
- EINECS: 208-884-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-12-15 17:16:12
What is DIMETHYLZINC?
Chemical properties
Clear colorless liquid
The Uses of DIMETHYLZINC
Dimethylzinc is pharmaceutical compound comprising Hemiasterlin derivatives and its antibody conjugate for treatment of cancer.
The Uses of DIMETHYLZINC
Activator for radical trifluoromethylation of silyl enol ethers leading to α-trifluoromethyl ketones.1
The Uses of DIMETHYLZINC
Dimethylzinc solution can be used as:
- A catalyst with nickel for the stereoselective C?2 alkenylation and dialkenylation of pyridine derivatives by alkynes to give monoalkenylation products.
- A reagent with aldehydes and 2-methoxyaniline for the synthesis of enantioselective alkyl and aralkyl secondary amines via one-pot three-component coupling reaction in the presence of zirconium tetraisopropoxide.
- A methylating reagent for methylation of fluoroalkylated pyruvates in the presence of copper/chiral diphosphine catalyst.
Definition
ChEBI: Dimethylzinc is a dialkylzinc compound.
General Description
Mobile liquid, with peculiar garlic odor.
Air & Water Reactions
Highly flammable. Ignites in air and burns with a blue flame giving off a peculiar garlicky odor. Explodes in oxygen or ozone. Reacts violently with water to generate methane [Merck, 11th ed., 1989; Brauer(1965)]. Very slow oxidation with traces of air to give methylzinc methylate.
Reactivity Profile
DIMETHYLZINC is very reactive, acts as a strong reducing agent. Combines with acids, with alcohols (methanol, ethanol), and 2-2-dichloropropane as well as with water with explosive violence. When heated to decomposition emits toxic fumes of zinc oxide [Bretherick, 5th ed., 1995, p. 354]. Oxidants may yield peroxide formation, which is explosive.
Health Hazard
Inhalation of mist or vapor causes immediate irritation of upper respiratory tract. Excessive or prolonged inhalation of fumes from ignition or decomposition may cause ``metal fume fever'' (sore throat, headache, fever, chills, nausea, vomiting, muscular aches, perspiration, constricting sensation in lungs, weakness, sometimes prostration). Symptoms usually last 12-24 hrs. Eyes are immediately and severely irritated by liquid, vapor, or dilute solutions. If not removed by thorough flushing with water, chemical may permanently damage cornea. Skin will undergo thermal and acid burns when chemical reacts with moisture in skin. Unless washed quickly, skin may be scarred. Treat dilute solutions with same precautions as concentrated liquid. Ingestion, while unlikely, would cause immediate burns at site of contact. Nausea, vomiting, cramps, and diarrhea may follow. Tissues may ulcerate if not treated.
Properties of DIMETHYLZINC
Melting point: | -42°C |
Boiling point: | 44-46 °C |
Density | 0.92 g/mL at 20 °C |
Flash point: | 30 °F |
storage temp. | 0-6°C
|
form | liquid |
color | colorless |
Sensitive | Air & Moisture Sensitive |
Merck | 14,3263 |
BRN | 3587195 |
CAS DataBase Reference | 544-97-8(CAS DataBase Reference) |
EPA Substance Registry System | Zinc, dimethyl- (544-97-8) |
Safety information for DIMETHYLZINC
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Health Hazard GHS08 Environment GHS09 |
GHS Hazard Statements |
H225:Flammable liquids H250:Pyrophoric liquids; Pyrorophoric solids H252:Self-heating substances and mixtures H260:Substances And Mixtures Which, In Contact With Water,Emit Flammable Gases H261:Substances And Mixtures Which, In Contact With Water,Emit Flammable Gases H304:Aspiration hazard H314:Skin corrosion/irritation H318:Serious eye damage/eye irritation H336:Specific target organ toxicity,single exposure; Narcotic effects H373:Specific target organ toxicity, repeated exposure H400:Hazardous to the aquatic environment, acute hazard H410:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P222:Do not allow contact with air. P223:Keep away from any possible contact with water, because of violent reaction and possible flash fire. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P231+P232:Handle under inert gas. Protect from moisture. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P370+P378:In case of fire: Use … for extinction. P405:Store locked up. P422:Store contents under … |
Computed Descriptors for DIMETHYLZINC
InChIKey | AXAZMDOAUQTMOW-UHFFFAOYSA-N |
Abamectin manufacturer
JSK Chemicals
HYCHEM LABORATORIES
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