Dimethyl 5-hydroxyisophthalate

Synonym(s):Dimethyl 5-hydroxybenzene-1,3-dicarboxylate

CAS NO.：13036-02-7
Empirical Formula: C10H10O5
Molecular Weight: 210.18
MDL number: MFCD00134367
EINECS: 235-899-0
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-25 18:01:14

Dimethyl 5-hydroxyisophthalate Structural

What is Dimethyl 5-hydroxyisophthalate?

Chemical properties

off-white crystal powder

The Uses of Dimethyl 5-hydroxyisophthalate

Dimethyl 5-Hydroxyisophthalate is a useful synthetic intermediate in the synthesis of N,N?-Bis(2,3-dihydroxypropyl)-5-[(N-(2-hydroxyethyl)carbamoyl)methoxy]-2,4,6-triiodoisophthalamide (B426310); a compound related to Ioversol( I737000) which is a nonionic, low osmolality, radiographic contrast agent.

General Description

Dimethyl 5-hydroxyisophthalate undergoes a base-catalyzed nucleophilic oxirane ring-opening addition reaction with allyl glycidyl ether, to afford 5-substituted derivatives of isophthalic acid. Influence of third component, i.e. a series of 1,ω-alkanediols on the copolymerization reaction of dimethyl 5-hydroxyisophthalate with poly(ethylene glycol) has been studied. Lipase-catalyzed condensation polymerization of dimethyl 5-hydroxyisophthalate with polyethylene glycol is reported.

Properties of Dimethyl 5-hydroxyisophthalate

Melting point:	162-164 °C (lit.)
Boiling point:	360.6±22.0 °C(Predicted)
Density	1.284±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Powder and/or Lumps
pka	8.33±0.10(Predicted)
color	White to light beige
Water Solubility	Soluble in water.
BRN	2650120
CAS DataBase Reference	13036-02-7(CAS DataBase Reference)
EPA Substance Registry System	Dimethyl 5-hydroxyisophthalate (13036-02-7)

Safety information for Dimethyl 5-hydroxyisophthalate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.