dimebolin
Synonym(s):2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrochloride hydrate;Dimebolin dihydrochloride hydrate;Dimeboline dihydrochloride hydrate;Dimebone dihydrochloride hydrate
- CAS NO.:3613-73-8
- Empirical Formula: C21H25N3
- Molecular Weight: 319.44
- MDL number: MFCD00387540
- EINECS: 638-815-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:03:06
What is dimebolin?
The Uses of dimebolin
Non-steroidal anti-inflammatory with analgesic and antipyretic effects
Definition
ChEBI: Latrepirdine is a member of methylpyridines and a pyridoindole. It has a role as a geroprotector.
Biological Activity
dimebolin is an orally-available antihistamine drug with a long history of clinical use in russia [1][2][3][4].dimebolin has been proposed to be useful for treating neurodegenerative disorders, including alzheimer's disease (ad) and huntington's disease (hd). dimebon might exhibit efficacy by blocking nmda receptors or voltage-gated ca2+ channels and by preventing mitochondrial permeability pore transition [3].dimebolin is an orally-available antihistamine drug. dimebon improved survival of cerebellar granule cells during long-term incubation with aβ25-35. dimebolin also blocked potential-dependent ca(2+) entry into neurons by about 20% by blocking l-type ca(2+) channels [4]. in the cerebellum cell culture, dimebolin protected neurons against the neurotoxic action of aβ25-35 with ec50 value of 25 μm. on isolated rat ileum intestine, dimebolin displayed ca2+-blocking properties with ic50 value of 57 μm. dimebon also exhibited anticholinesterase activity with ic50 values of 7.9 μm and 42 μm for butyryl-choline esterase and acetylcholine esterase, respectively [5].in rats treated with the neurotoxin af64a, dimebolin exhibited cognition and memory-enhancing properties. in mice, dimebolin prevented nmda-induced seizures with ec50 value of 42 ± 6 mg/kg [5].
References
[1]. lermontova nn, lukoyanov nv, serkova tp, et al. dimebon improves learning in animals with experimental alzheimer's disease. bull exp biol med. 2000 jun;129(6):544-6.
[2]. doody rs, gavrilova si, sano m, et al. effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate alzheimer's disease: a randomised, double-blind, placebo-controlled study. lancet. 2008 jul 19;372(9634):207-15.
[3]. wu j, li q, bezprozvanny i. evaluation of dimebon in cellular model of huntington's disease. mol neurodegener. 2008 oct 21;3:15.
[4]. lermontova nn, redkozubov ae, shevtsova ef, et al. dimebon and tacrine inhibit neurotoxic action of beta-amyloid in culture and block l-type ca(2+) channels. bull exp biol med. 2001 nov;132(5):1079-83.
[5]. bachurin s, bukatina e, lermontova n, et al. antihistamine agent dimebon as a novel neuroprotector and a cognition enhancer. ann n y acad sci. 2001 jun;939:425-35.
Properties of dimebolin
Melting point: | 115-116 °C |
Boiling point: | 448.46°C (rough estimate) |
Density | 1.13 |
refractive index | 1.6380 (estimate) |
storage temp. | Store at -20°C |
solubility | ≤30mg/ml in ethanol;1mg/ml in DMSO;3mg/ml in dimethyl formamide |
form | crystalline solid |
pka | 9.05±0.20(Predicted) |
CAS DataBase Reference | 3613-73-8 |
Safety information for dimebolin
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H320:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for dimebolin
New Products
(R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin F Tubulysin B Tubulysin G Tubulysin E Tubulysin C 3-N-BOC-(S)-AMINO BUTYRONITRILE 2,2,6,6-tetramethyl-2H-3,5,6-trihydropyran-4-one tetrahydro-4-methyl-2H-pyran 2,2-Difluoropropanol (S)-(+)-3-HYDROXYTETRAHYDROFURAN 3,6-Dihydro-2H-pyran-4-carbonitrile 2-Amino-3-bromo-5-nitropyridine 5-Nitrobarbituric acid N-[2-(Acetylthio)-1-oxobutyl]glycine ethyl ester 4-chloro-2-hydroxy-5-nitropyridine methyl 2-bromobenzoate 5-Bromo-2-chloroisonicotinic acid 7-Methoxyquinoline-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acid 1H-Imidazole-4-carbonitrile Solifenacin Ethyl Ester Impurity / Solifenacin Acid Ethyl Ester Quetiapine S-Oxide 7-Hydroxy Metabolite Methylprednisolone Acetate EP Impurity IRelated products of tetrahydrofuran
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