dimebolin
Synonym(s):2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrochloride hydrate;Dimebolin dihydrochloride hydrate;Dimeboline dihydrochloride hydrate;Dimebone dihydrochloride hydrate
- CAS NO.:3613-73-8
- Empirical Formula: C21H25N3
- Molecular Weight: 319.44
- MDL number: MFCD00387540
- EINECS: 638-815-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
![dimebolin Structural](https://img.chemicalbook.in/CAS/GIF/3613-73-8.gif)
What is dimebolin?
The Uses of dimebolin
Non-steroidal anti-inflammatory with analgesic and antipyretic effects
Definition
ChEBI: Latrepirdine is a member of methylpyridines and a pyridoindole. It has a role as a geroprotector.
Biological Activity
dimebolin is an orally-available antihistamine drug with a long history of clinical use in russia [1][2][3][4].dimebolin has been proposed to be useful for treating neurodegenerative disorders, including alzheimer's disease (ad) and huntington's disease (hd). dimebon might exhibit efficacy by blocking nmda receptors or voltage-gated ca2+ channels and by preventing mitochondrial permeability pore transition [3].dimebolin is an orally-available antihistamine drug. dimebon improved survival of cerebellar granule cells during long-term incubation with aβ25-35. dimebolin also blocked potential-dependent ca(2+) entry into neurons by about 20% by blocking l-type ca(2+) channels [4]. in the cerebellum cell culture, dimebolin protected neurons against the neurotoxic action of aβ25-35 with ec50 value of 25 μm. on isolated rat ileum intestine, dimebolin displayed ca2+-blocking properties with ic50 value of 57 μm. dimebon also exhibited anticholinesterase activity with ic50 values of 7.9 μm and 42 μm for butyryl-choline esterase and acetylcholine esterase, respectively [5].in rats treated with the neurotoxin af64a, dimebolin exhibited cognition and memory-enhancing properties. in mice, dimebolin prevented nmda-induced seizures with ec50 value of 42 ± 6 mg/kg [5].
References
[1]. lermontova nn, lukoyanov nv, serkova tp, et al. dimebon improves learning in animals with experimental alzheimer's disease. bull exp biol med. 2000 jun;129(6):544-6.
[2]. doody rs, gavrilova si, sano m, et al. effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate alzheimer's disease: a randomised, double-blind, placebo-controlled study. lancet. 2008 jul 19;372(9634):207-15.
[3]. wu j, li q, bezprozvanny i. evaluation of dimebon in cellular model of huntington's disease. mol neurodegener. 2008 oct 21;3:15.
[4]. lermontova nn, redkozubov ae, shevtsova ef, et al. dimebon and tacrine inhibit neurotoxic action of beta-amyloid in culture and block l-type ca(2+) channels. bull exp biol med. 2001 nov;132(5):1079-83.
[5]. bachurin s, bukatina e, lermontova n, et al. antihistamine agent dimebon as a novel neuroprotector and a cognition enhancer. ann n y acad sci. 2001 jun;939:425-35.
Properties of dimebolin
Melting point: | 115-116 °C |
Boiling point: | 448.46°C (rough estimate) |
Density | 1.13 |
refractive index | 1.6380 (estimate) |
storage temp. | Store at -20°C |
solubility | ≤30mg/ml in ethanol;1mg/ml in DMSO;3mg/ml in dimethyl formamide |
form | crystalline solid |
pka | 9.05±0.20(Predicted) |
CAS DataBase Reference | 3613-73-8 |
Safety information for dimebolin
Signal word | Warning |
Pictogram(s) |
![]() Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H320:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for dimebolin
New Products
Cycloleucine 1-Amino-1-cyclohexanecarboxylic acid 6-Bromo-3-iodo-1-methyl-1H-indazole 3-(2,4-Dimethoxybenzyl)dihydropyrimidine-2,4(1H,3H)-dione ELECTROLYTIC IRON POWDER 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) 4-HYDROXY BENZYL ALCOHOL S-2-CHLORO PROPIONIC ACID 1-Aminocyclobutanecarboxylic acid 1-(2-Ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole hydrochloride 5-BROMO-2CYANO PYRIDINE 2-(BOC-Amino)4-picoline tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate Decanonitrile 4-Ethylbenzylamine N-(5-Amino-2-methylphenyl)acetamide 1-(4-Methylphenylsulfonyl)-1H-1,2,3-benzotriazole 5-Bromo-2,3-dimethoxypyridine 2-Chloro-3-nitropyridine (4-chloro-2,6-difluorophenyl)methanamine 4-chloro-2,3-diaminopyridine 6-bromo-5-cyano quinolineRelated products of tetrahydrofuran
![Boc-3-Hydroxy-1-adamantyl-D-glycine](https://img.chemicalbook.in/CAS/GIF/361442-00-4.gif)
![Saxagliptin](https://img.chemicalbook.in/CAS/GIF/361442-04-8.gif)
![Dapagliflozin](https://img.chemicalbook.in/CAS/20180808/GIF/461432-26-8.gif)
![Tetrahydrofurfuryl alcohol](https://img.chemicalbook.in/CAS/GIF/97-99-4.gif)
![dimebolin](https://img.chemicalbook.in/CAS/GIF/3613-73-8.gif)
![3-Pyridineethaneamine](https://img.chemicalbook.in/CAS/GIF/20173-24-4.gif)
![5-METHYLGRAMINE](https://img.chemicalbook.in/CAS/GIF/30218-58-7.gif)
![2-METHYL-3-N,N-DIMETHYLAMINOMETHYLINDOLE](https://img.chemicalbook.in/CAS/GIF/37125-92-1.gif)
You may like
-
Dimebolin 95% CAS 3613-73-8View Details
3613-73-8 -
7440-57-5 collodial goldView Details
7440-57-5 -
127-06-0 min 99%View Details
127-06-0 -
collodial silver 1000 ppm 1018 ppm %View Details
7440-22-4 -
butyl hexanoate 626-82-4 99%View Details
626-82-4 -
citraconic anhydride 98.90%View Details
616-02-4 -
111-64-8 octynaoyl chloride 99%View Details
111-64-8 -
Diethyltoluamide 99.30%View Details
134-62-3