Dibenzepin
- CAS NO.:4498-32-2
- Empirical Formula: C18H21N3O
- Molecular Weight: 295.38
- MDL number: MFCD00865354
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:44:00
What is Dibenzepin?
Chemical properties
Crystalline Solid
Originator
Noveril ,Wander,Switz.,1965
The Uses of Dibenzepin
Antidepressant
Background
Dibenzepin is approved for use in Europe.
What are the applications of Application
Dibenzepin is a norepinephrine reuptake inhibitor
Definition
ChEBI: 5-[2-(dimethylamino)ethyl]-11-methyl-6-benzo[b][1,4]benzodiazepinone is a dibenzodiazepine.
Manufacturing Process
4.48 grams of 5-methyl-11-hydroxy-5H-dibenzo[b,e][1,4]diazepine and 0.86
gram of sodium amide were boiled for one hour in 50 ml of absolute dioxane.
After adding a concentrated benzenic solution of β-dimethylamino-ethyl
chloride freshly prepared from 3.75 grams of the hydrochloride with
concentrated sodium hydroxide solution, taking up in benzene and drying the
solution with potash, the mixture was boiled for 16 hours under reflux,
whereupon the reaction mixture was concentrated to dryness and the residue
distributed between ether and water. By exhaustive extraction of the basic
fractions with dilute acetic acid, precipitation with ammonia, taking up the
base in ether and working up the ethereal solution, there was obtained 5.05
grams (85% of the theoretical) of 5-methyl-10-β-dimethylamino-ethyl-10,11-
dihydro-11-oxo-5H-dibenzo[b,e][1,4]diazepine in the form of a viscous
yellowish resin with the boiling point 185°C/0.01mm Hg. The base was
crystallized from acetone-petroleum ether, MP 116°-117°C. Melting point of
the monohydrochloride (from ethanol-ether) 234°-240°C.
Therapeutic Function
Psychostimulant
Metabolism
Not Available
Properties of Dibenzepin
Melting point: | 116-117°C |
Boiling point: | bp0.01 185° |
Density | 1.1190 (rough estimate) |
refractive index | 1.5855 (estimate) |
storage temp. | Refrigerator |
solubility | Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly) |
pka | 8.25(at 25℃) |
form | Solid |
color | Light Beige to Brown |
CAS DataBase Reference | 4498-32-2 |
Safety information for Dibenzepin
Computed Descriptors for Dibenzepin
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