Propyphenazone
Synonym(s):1,2-Dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3H-pyrazol-3-one;1,2-Dihydro-4-isopropyl-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one;4-Isopropylantipyrine;Isopropylphenazone;Propyphenazone
- CAS NO.:479-92-5
- Empirical Formula: C14H18N2O
- Molecular Weight: 230.31
- MDL number: MFCD00053368
- EINECS: 207-539-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-08 21:13:59
What is Propyphenazone?
Description
This uncharacterized alkaloid has been described by Hartsen as occurring in Iso_x0002_pyrum thalictroides L. No chemical or physical characteristics are known.
Chemical properties
solid
The Uses of Propyphenazone
Analgesic; antipyretic; anti-inflammatory.
Definition
ChEBI: A pyrazolone derivative that is antipyrine substituted at C-4 by an isopropyl group.
What are the applications of Application
Propyphenazone is an analgesic, antipyretic, and anti-inflammatory
brand name
539 grippe-dragees;Amipylo-n;Balpiren;Baukal;Caffalgina;Camoplex;Cantacin;Cerebrol;Daturmed;Degripol;Dentocaps a;Dim-antos;Dolibral;Dolo-mineuron;Dysmalgin;Ejcopyrin;Epizon;Escomen;Estesina;Fd 8;Febral;Finigripp;Grippocaps;Heaven;Infantex;Influvit;Isopronazon;Kavapyret;Kuronde;Lysadestat;Mamaslu;Milneuron;Myo-europan;Neuramin;Neuridal;Neuro-spondryl;Nodiras;Noric;Otobacid;Pfeil;Reomin;Retamex;Rheumanol;Rhinivict;Sanalgin-p;Saridon neu;Saridone;Sedospin;Servalgin;Sonotryl;Spalt;Spongamed;Stona;Synpyrin;Vivcet;Wauco-sin;Wecontrin.
World Health Organization (WHO)
Propyphenazone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1951 for the treatment of rheumatic disorders. As it is structurally related to aminophenazone it has been associated with severe blood dyscrasias. However, it cannot be transformed into potentially carcinogenic nitrosamines and has therefore been widely used as a replacement drug for aminophenazone. In certain countries, products containing propyphenazone have now been restricted in their indications, whereas in others they are still available, sometimes as over-the-counter preparations. See also WHO comment for aminophenazone.
Clinical Use
Propyphenazone is a derivative of phenazone and has a similar analgesic and antipyretic action. It is used as a monocompound as well as in multi-ingredient preparations.
References
Hartsen., J. Chem. Soc., 511 (1873) Mirande., Compt. rend., 168,316 (1919)
Properties of Propyphenazone
Melting point: | 102-105°C |
Boiling point: | 372.3°C (rough estimate) |
Density | 1.0371 (rough estimate) |
refractive index | 1.5500 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | Slightly soluble in water, freely soluble in ethanol (96 per cent) and in methylene chloride. |
form | neat |
pka | 1.46±0.65(Predicted) |
form | Solid |
color | White to Off-White |
Water Solubility | 743.6g/L(25.35 ºC) |
Merck | 14,7871 |
BRN | 204533 |
Stability: | Stable. Incompatible with strong oxidizing agents. |
CAS DataBase Reference | 479-92-5(CAS DataBase Reference) |
NIST Chemistry Reference | Propyphenazone(479-92-5) |
EPA Substance Registry System | 3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl- (479-92-5) |
Safety information for Propyphenazone
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for Propyphenazone
Abamectin manufacturer
Ralington Pharma
SETV ASRV LLP
New Products
COBALT AAS SOLUTION HYDROXYLAMINE HYDROCHLORIDE SOLUTION 10% THOMALIT BLUE LITMUS PAPER 1 BOX SILVER NITRATE N/10 CVS GLASS BEADS 3.5 TO 4.5 MM POTASSIUM AAS SOLUTION Azithromycin Imp D Atracurium Besylate EP Impurity C Ceftaroline fosamil Acetate Hydrate Clarithromycin EP impurity F Clarithromycin EP Impurity D Clindamycin BRelated products of tetrahydrofuran
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