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HomeProduct name listPropyphenazone

Propyphenazone

Synonym(s):1,2-Dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl-3H-pyrazol-3-one;1,2-Dihydro-4-isopropyl-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one;4-Isopropylantipyrine;Isopropylphenazone;Propyphenazone

  • CAS NO.:479-92-5
  • Empirical Formula: C14H18N2O
  • Molecular Weight: 230.31
  • MDL number: MFCD00053368
  • EINECS: 207-539-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-08 21:13:59
Propyphenazone Structural

What is Propyphenazone?

Description

This uncharacterized alkaloid has been described by Hartsen as occurring in Iso_x0002_pyrum thalictroides L. No chemical or physical characteristics are known.

Chemical properties

solid

The Uses of Propyphenazone

Analgesic; antipyretic; anti-inflammatory.

Definition

ChEBI: A pyrazolone derivative that is antipyrine substituted at C-4 by an isopropyl group.

What are the applications of Application

Propyphenazone is an analgesic, antipyretic, and anti-inflammatory

brand name

539 grippe-dragees;Amipylo-n;Balpiren;Baukal;Caffalgina;Camoplex;Cantacin;Cerebrol;Daturmed;Degripol;Dentocaps a;Dim-antos;Dolibral;Dolo-mineuron;Dysmalgin;Ejcopyrin;Epizon;Escomen;Estesina;Fd 8;Febral;Finigripp;Grippocaps;Heaven;Infantex;Influvit;Isopronazon;Kavapyret;Kuronde;Lysadestat;Mamaslu;Milneuron;Myo-europan;Neuramin;Neuridal;Neuro-spondryl;Nodiras;Noric;Otobacid;Pfeil;Reomin;Retamex;Rheumanol;Rhinivict;Sanalgin-p;Saridon neu;Saridone;Sedospin;Servalgin;Sonotryl;Spalt;Spongamed;Stona;Synpyrin;Vivcet;Wauco-sin;Wecontrin.

World Health Organization (WHO)

Propyphenazone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1951 for the treatment of rheumatic disorders. As it is structurally related to aminophenazone it has been associated with severe blood dyscrasias. However, it cannot be transformed into potentially carcinogenic nitrosamines and has therefore been widely used as a replacement drug for aminophenazone. In certain countries, products containing propyphenazone have now been restricted in their indications, whereas in others they are still available, sometimes as over-the-counter preparations. See also WHO comment for aminophenazone.

Clinical Use

Propyphenazone is a derivative of phenazone and has a similar analgesic and antipyretic action. It is used as a monocompound as well as in multi-ingredient preparations.

References

Hartsen., J. Chem. Soc., 511 (1873) Mirande., Compt. rend., 168,316 (1919)

Properties of Propyphenazone

Melting point: 102-105°C
Boiling point: 372.3°C (rough estimate)
Density  1.0371 (rough estimate)
refractive index  1.5500 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  Slightly soluble in water, freely soluble in ethanol (96 per cent) and in methylene chloride.
form  neat
pka 1.46±0.65(Predicted)
form  Solid
color  White to Off-White
Water Solubility  743.6g/L(25.35 ºC)
Merck  14,7871
BRN  204533
Stability: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference 479-92-5(CAS DataBase Reference)
NIST Chemistry Reference Propyphenazone(479-92-5)
EPA Substance Registry System 3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(1-methylethyl)-2-phenyl- (479-92-5)

Safety information for Propyphenazone

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501:Dispose of contents/container to..…

Computed Descriptors for Propyphenazone

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