DIBENZEPINE HCL
- CAS NO.:315-80-0
- Empirical Formula: C18H22ClN3O
- Molecular Weight: 331.84
- MDL number: MFCD00798249
- EINECS: 206-255-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:37
What is DIBENZEPINE HCL?
Originator
Noveril ,Wander,Switz.,1965
The Uses of DIBENZEPINE HCL
Antidepressant.
What are the applications of Application
Dibenzepine HCl is a tricyclic antidepressant antipsychotic small molecule
Definition
ChEBI: Dibenzepin hydrochloride is a dibenzodiazepine.
Manufacturing Process
4.48 grams of 5-methyl-11-hydroxy-5H-dibenzo[b,e][1,4]diazepine and 0.86
gram of sodium amide were boiled for one hour in 50 ml of absolute dioxane.
After adding a concentrated benzenic solution of β-dimethylamino-ethyl
chloride freshly prepared from 3.75 grams of the hydrochloride with
concentrated sodium hydroxide solution, taking up in benzene and drying the
solution with potash, the mixture was boiled for 16 hours under reflux,
whereupon the reaction mixture was concentrated to dryness and the residue
distributed between ether and water. By exhaustive extraction of the basic
fractions with dilute acetic acid, precipitation with ammonia, taking up the
base in ether and working up the ethereal solution, there was obtained 5.05
grams (85% of the theoretical) of 5-methyl-10-β-dimethylamino-ethyl-10,11-
dihydro-11-oxo-5H-dibenzo[b,e][1,4]diazepine in the form of a viscous
yellowish resin with the boiling point 185°C/0.01mm Hg. The base was
crystallized from acetone-petroleum ether, MP 116°-117°C. Melting point of
the monohydrochloride (from ethanol-ether) 234°-240°C.
brand name
Deprex;Ecatrol;Hf 1927;Neodit;Victoril.
Therapeutic Function
Psychostimulant
World Health Organization (WHO)
Dibenzepin hydrochloride, a tricyclic antidepressant, was introduced in 1968 for the treatment of depressive illness. By 1973 its use in Sweden had been associated with an unexpectedly high number of suicide attempts which led to its withdrawal in that country. Although its use has lapsed in several countries, it remains available in at least eight European countries.
Properties of DIBENZEPINE HCL
Melting point: | 238° |
pka | 8.25(at 25℃) |
Safety information for DIBENZEPINE HCL
Computed Descriptors for DIBENZEPINE HCL
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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