Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listDantrolene sodium salt

Dantrolene sodium salt

Synonym(s):1-[(5--(p-Nitro-phenyl)-fur-furyl-idene)-amino]-hydan-toin sodium salt;Dantrolene, Sodium Salt - CAS 14663-23-1 - Calbiochem

  • CAS NO.:14663-23-1
  • Empirical Formula: C14H11N4NaO5
  • Molecular Weight: 338.25
  • MDL number: MFCD00079130
  • EINECS: 238-706-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-09 19:38:33
Dantrolene sodium salt Structural

What is Dantrolene sodium salt?

Description

Dantrolene is an inhibitor of calcium release from the sarcoplasmic reticulum (IC50 = 0.3 μM). It binds to sarcoplasmic reticulum vesicles isolated from normal and malignant hyperthermia-susceptible (MHS) pigs with Kd values of 0.3 and 0.09 μM, respectively. Dantrolene reduces spontaneous calcium wave frequency and amplitude in the presence of calmodulin in isolated mouse cardiomyocytes with IC50 values of 0.42 and 0.19 μM, respectively. It reduces the magnitude of electrically stimulated twitch tensions in isolated rat extensor digitorum longus and soleus muscles (IC50 = 3 μg/ml) and MHS pigs (ED50 = 0.85 mg/kg). Formulations containing dantrolene have been used in the treatment of malignant hyperthermia.

Chemical properties

mp 279-280C 3415821

The Uses of Dantrolene sodium salt

Dantrolene Sodium Salt is a skeletal muscle relaxant, which inhibits intracellular Ca 2+release from the sarcoplasmic reticulum.

The Uses of Dantrolene sodium salt

Skeletal muscle relaxant;Blocker of Ca2+ release

What are the applications of Application

Dantrolene sodium salt is a calcium channel protein inhibitor

Definition

ChEBI: The anhydrous sodium salt of dantrolene.

brand name

Dantrium (Procter & Gamble).

Biological Activity

Inhibits release of Ca 2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.

storage

Store at RT

References

1) Zhao?et al.?(2001),?Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity; J. Biol. Chem.,?276?13810 2) Frandsen and Schousboe (1992),?Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate and kainite in cultured cerebral cortical neurons; Proc. Natl. Acad. Sci. USA,?89?2590 3) Muehlschlegel and Sims (2009),?Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit; Neuro. Crit. Care,?10?103 4) Lu?et al.?(2014),?A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome; Proc. Natl. Acad. Sci. USA,?111?E5292

Properties of Dantrolene sodium salt

storage temp.  Store at RT
solubility  Soluble in DMSO (up to 3 mg/ml)
form  Orange solid
color  Orange
Merck  14,2816
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF/ethanol may be stored at -20°C for up to 1 month.
CAS DataBase Reference 14663-23-1(CAS DataBase Reference)

Safety information for Dantrolene sodium salt

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for Dantrolene sodium salt

InChIKey KSRLIXGNPXAZHD-HAZZGOGXSA-M

Related products of tetrahydrofuran

You may like

  • 14663-23-1 Dantrolene Sodium 99%
    14663-23-1 Dantrolene Sodium 99%
    14663-23-1
    View Details
  • 14663-23-1 98%
    14663-23-1 98%
    14663-23-1
    View Details
  • DANTROLENE SODIUM SALT CAS 14663-23-1
    DANTROLENE SODIUM SALT CAS 14663-23-1
    14663-23-1
    View Details
  • Dantrolene sodium salt hydrate 98.00% CAS 14663-23-1
    Dantrolene sodium salt hydrate 98.00% CAS 14663-23-1
    14663-23-1
    View Details
  • Dantrolene sodium salt hydrate 98% CAS 14663-23-1
    Dantrolene sodium salt hydrate 98% CAS 14663-23-1
    14663-23-1
    View Details
  • Dantrolene Sodium Salt Hydrate CAS 14663-23-1
    Dantrolene Sodium Salt Hydrate CAS 14663-23-1
    14663-23-1
    View Details
  • Dantrolene sodium salt CAS 14663-23-1
    Dantrolene sodium salt CAS 14663-23-1
    14663-23-1
    View Details
  • Dantrolene, Sodium Salt CAS 14663-23-1
    Dantrolene, Sodium Salt CAS 14663-23-1
    14663-23-1
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.