D-Serine
Synonym(s):β-Hydroxyalanine;(R)-2-Amino-3-hydroxypropionic acid;Ser
- CAS NO.:312-84-5
- Empirical Formula: C3H7NO3
- Molecular Weight: 105.09
- MDL number: MFCD00004269
- EINECS: 206-229-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-16 10:38:43
What is D-Serine?
Description
Serine is one of the 20 naturally-occurring amino acids used by all organisms in the biosynthesis of proteins. Having a single chiral center, serine can exist as one of two stereoisomers (L-Serine and D-Serine).
D-serine is categorized as a nootropic. It is an amino acid found in the brain and is produced primarily in astrocytes; the conversion of L-serine to D-serine is catalyzed by the serine racemase enzyme. D-serine acts as a co-agonist of glutamate NMDA receptors and binds at the glycine site. NMDA receptors mediate synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition, and learning. Schizophrenia is characterized by reduced NMDA receptor signaling and therefore, D-serine supplementation has been tested extensively in patients with schizophrenia. It is thought to improve cognitive symptoms in this population. It is worth noting that in Alzheimer’s disease, there is excess glutamate receptor activation. Memantine, one of the drugs used to treat Alzheimer’s disease, is an NMDA receptor antagonist.
The Uses of D-Serine
D-Serine is involved in the biosynthesis of purines, pyrimidines, and other amino acids. D-Serine also is an agonist of glycine site of the NMDA-type glutamate receptor. It also acts as Lacosamide intermediate.
Background
A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids. [PubChem]
What are the applications of Application
D-Serine is a non-essential amino acid involved in the biosynthesis of amino acids
Metabolism
Not Available
Properties of D-Serine
Melting point: | 220 °C |
Boiling point: | 197.09°C (rough estimate) |
Density | 1.3895 (rough estimate) |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | H2O: 0.1 g/mL, clear, colorless |
form | Crystalline Powder |
color | White |
Water Solubility | 346 g/L (20 ºC) |
Safety information for D-Serine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for D-Serine
InChIKey | MTCFGRXMJLQNBG-UWTATZPHSA-N |
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