L(+)-Lactic acid

Description

L-Lactic acid, also known as ( )-lactic acid and milk acid, exists in small quantities in the blood and muscle fluid of animals, including humans. Vigorous activity increases the amount of L-lactic acid in these fluids. In 1780, C. W. Scheele isolated the acid from fermented milk and purified it. In 1856, L. Pasteur discovered that Lactobacillus bacteria produce L-lactic acid, and this became the basis for the first commercial manufacturing plant to produce the acid (1895).

Chemical properties

Crystalline Solid

The Uses of L(+)-Lactic acid

Occurs in small quantities in the blood and muscle fluid of man and animals. The lactic acid concentration increases in muscle and blood after vigorous activity. L-(+)-Lactic acid is also present in liver, kidney, thymus gland, human amniotic fluid, and o

The Uses of L(+)-Lactic acid

It is most commonly used for fluid resuscitation after blood loss due to trauma, surgery, or burn injury. It is used in the agricultural, chemical, leather processing, pharmaceuticals, and cosmetics industries, used as an electroplating agent, food/feed additive, pH regulator, cleaning/washing agent, and tanning agent; used to flavor animal feeds; used as a solvent and intermediate in chemical production, as a pH regulator in fabric finishing, and in paints, coatings, soaps, and cleaning products; used to make large scale and fine chemicals, pulp-paper-paper products, food products, and plastic products, in mining, health services, agriculture-forestry-fishing, and building and construction work.

The Uses of L(+)-Lactic acid

Lactic acid has been used:

• as a component in substrate solution II for lactate dehydrogenase reaction
• as an additive in storage solution A
• as a supplement in the artificial gastric juice preparation for evaluation of degree of resistance Lactobacillus to the gastric stresses

What are the applications of Application

L-(+)-Lactic acid solution, 1M is an aqueous solution of 1M L-lactic acid in water. ≤1% D-lactic acid

What are the applications of Application

L-(+)-Lactic acid Solution is a substrate for lactic acid dehydrogenase (LDH) enzymes

Definition

ChEBI: An optically active form of lactic acid having (S)-configuration.

General Description

L-(+)-Lactic acid is the only naturally occurring lactic acid in humans and mammals. Commercially, few bacteria like Lactobacillus casei, L. delbrueckii, Streptococcus lactis produces L-Lactic acid by fermentation process. Lactic acid activates hydroxycarboxylic acid receptor, G-protein coupled receptor 81 (GPR81).

Flammability and Explosibility

Not classified

Biochem/physiol Actions

L-(+)-Lactic acid is used as a substrate for lactic acid dehydrogenase and lactate oxidase.

Metabolism

Not Available

Purification Methods

Purify lactic acid by fractional distillation at 0.1mm pressure, followed by fractional crystallisation from diethyl ether/isopropyl ether (1:1, dried with sodium). [Borsook et al. J Biol Chem 102 449 1933.] The solvent mixture, *benzene/diethyl ether (1:1) containing 5% pet ether (b 60-80o) has also been used. [Brin Biochemical Preparations 3 61 1953, Beilstein 3 IV 633.]