D-Valine

Synonym(s):(R)-α-Aminoisovaleric acid;D-2-Amino-3-methylbutanoic acid

CAS NO.：640-68-6
Empirical Formula: C5H11NO2
Molecular Weight: 117.15
MDL number: MFCD00064219
EINECS: 211-368-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:08:57

What is D-Valine?

Chemical properties

white to off-white crystalline powder

The Uses of D-Valine

D-Valine is an isomer of the essential amino acid L-Valine. D-Valine has been used as a selective agent in epithelial cells in culture since it inhibits cells that lack the enzyme D-amino acid oxidase . D-Valine has also been shown to inhibit proliferation of contaminating fibroblasts in smooth muscle cells from human myometrium. D-Valine solution showed tumor growth inhibition and improvements of the nutritional status in AH109A hepatoma-bearing rats.

The Uses of D-Valine

D-Valine is an isomer of the essential amino acid L-Valine. D-Valine has been used as a selective agent in epithelial cells in culture since it inhibits cells that lack the enzyme D-amino acid oxidase. D-Valine has also been shown to inhibit proliferation of contaminating fibroblasts in smooth muscle cells from human myometrium. D-Valine solution showed tumor growth inhibition and improvements of the nutritional status in AH109A hepatoma-bearing rats.

What are the applications of Application

D-Valine is an isomer of the essential amino acid L-Valine

Definition

ChEBI: The D-enantiomer of valine.

General Description

L-Valine is an essential non-polar amino acid. D-Valine is the non-proteinogenic isomer of valine.

Biochem/physiol Actions

D-valine is used in cell culture as a selective inhibitor of cell proliferation, wherein it inhibits cells that lack the enzyme D-amino acid oxidase. Historically D-valine has been used to inhibit fibroblast growth while allowing selective growth of epithelial cells.

Properties of D-Valine

Melting point:	>295 °C (subl.)(lit.)
Boiling point:	213.6±23.0 °C(Predicted)
alpha	-27.5 º (c=5, 5N HCl)
Density	1.2000 (estimate)
refractive index	-27 ° (C=8, 6mol/L HCl)
storage temp.	room temp
solubility	56 g/L (20°C)
form	Crystalline Powder
pka	2.37±0.10(Predicted)
color	White to off-white
optical activity	[α]23/D 32.0 to 24.0°, c = 8 in 6 M HCl
Water Solubility	56 g/L (20 ºC)
BRN	1721135
CAS DataBase Reference	640-68-6(CAS DataBase Reference)
NIST Chemistry Reference	2-Amino-3-methylbutanoic acid(D)(640-68-6)
EPA Substance Registry System	D-Valine (640-68-6)

Safety information for D-Valine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection.