CORTISOL-9,11,12,12-D4
Synonym(s):11β,17α,21-Trihydroxypregn-4-ene-3,20-dione-D4;11β,17α,21-Trihydroxypregn-4-ene-3,20-dione-d4 (9,11,12,12-d4);17-Hydroxycorticosterone-9,11,12,12-d4;17-Hydroxycorticosterone-D4;4-Pregnene-11β,17α,21-triol-3,20-dione-D4
- CAS NO.:73565-87-4
- Empirical Formula: C21H26D4O5
- Molecular Weight: 366.49
- MDL number: MFCD00144010
- EINECS: 694-327-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is CORTISOL-9,11,12,12-D4?
Description
Hydrocortisone-d4 is intended for use as an internal standard for the quantification of hydrocortisone/cortisol by GC- or LC-MS. Cortisol, known as hydrocortisone when used as a therapeutic, is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH). It is an agonist at the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR), with an approximately 6- to 10-fold greater affinity for MR. Cortisol production is increased during periods of stress, and it is a major effector molecule in the hypothalamic-pituitary-adrenal axis (HPA) stress response. Cortisol levels increase with age and are often elevated in major depressive disorder, certain forms of hypertension, and Parkinson''s disease.
Chemical properties
White Solid
The Uses of CORTISOL-9,11,12,12-D4
Anti-inflammatory hormone
The Uses of CORTISOL-9,11,12,12-D4
Labelled Cortisol (H714615). Cortisol, or Hydrocortisone, is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.
What are the applications of Application
Cortisol-9,11,12,12-d4 is principal, anti-inflammatory glucocorticoid hormon
General Description
Cortisol, also known as hydrocortisone, is a glucocorticoid produced by the adrenal gland. This stable labeled internal standard is suitable for quantitation of cortisol levels in whole blood by LC-MS/MS for newborn screening of congenital adrenal hyperplasia (CAH) and in serum or plasma by LC-MS/MS for determination of several diseases including Cushing′s syndrome, Addison′s disease, and Sheehan′s syndrome.
Properties of CORTISOL-9,11,12,12-D4
Melting point: | 211-214 °C |
Flash point: | 9℃ |
storage temp. | -20°C Freezer |
solubility | DMSO (Slightly), Ethanol (Slightly, Heated), Methanol (Slightly, Heated), Water |
form | Solid |
color | White to Off-White |
Safety information for CORTISOL-9,11,12,12-D4
Signal word | Warning |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H361:Reproductive toxicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for CORTISOL-9,11,12,12-D4
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