Cloxacillin-13C4 SodiuM Salt
- CAS NO.:642-78-4
- Empirical Formula: C19H19ClN3NaO5S
- Molecular Weight: 459.88
- MDL number: MFCD00150735
- EINECS: 211-390-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is Cloxacillin-13C4 SodiuM Salt?
Description
Cloxacillin is a β-lactam antibiotic and a derivative of oxacillin . It is active against clinical isolates of the Gram-positive bacteria S. aureus and S. epidermidis (MICs = 0.004-0.4 and 0.1-0.8 μg/ml, respectively) but not 34 Gram-negative bacteria (MICs = >128 μg/ml for all). Cloxacillin binds to S. aureus penicillin-binding protein 1 (PBP1), PBP2, PBP3, and PBP4 (IC50s = 0.04, 0.12, 0.21, and 2.5 μg/ml, respectively). It also binds to recombinant type Ib penicillinase, as well as P. vulgaris and C. freundii cephalosporinase (Kis = 15, 0.27, and 0.027 μM, respectively). Cloxacillin decreases the number of staphylococci in the mammary gland in a mouse model of acute, but not chronic, mastitis induced by Staphylococcus infection.
Chemical properties
White Crystalline Powder
Originator
Orbenin,Beecham,UK,1962
The Uses of Cloxacillin-13C4 SodiuM Salt
Cloxacillin-13C4 SodiuM Salt is an antibiotic that belongs to the group of the isoxazolylpenicillins. Cloxacillin is used to treat infections caused by species of staphylococci that produce beta-lactamase due to its inhibitory effects on beta-lactamase binding.
The Uses of Cloxacillin-13C4 SodiuM Salt
Cloxacillin-13C4 SodiuM Salt, an antibiotic that belongs to the group of the isoxazolylpenicillins. Cloxacillin is used to treat infections caused by species of staphylococci that produce beta-lac tamase due to its inhibitory effects on beta-lactamase binding.
The Uses of Cloxacillin-13C4 SodiuM Salt
Labelled S-Form of Dropropizine. Cough suppressive phenylpiperazine derivative. Antitussive.
The Uses of Cloxacillin-13C4 SodiuM Salt
Ropivacaine (R675000) metabolite.
What are the applications of Application
Cloxacillin sodium salt is an antibiotic
Definition
ChEBI: Cloxacillin sodium is an organic sodium salt. It contains a cloxacillin(1-).
Manufacturing Process
The reaction between 6-aminopenicillanic acid (6.5 g) and 3-o-chlorophenyl-5-
methylisoxazole4-carbonyl chloride (7.66 g) gave the sodium salt of 3-ochlorophenyl-5-methyl-4-isoxazolylpenicillin (9.98 g) as a pale yellow solid.
Colorimetric assay with hydroxylamine against a benzylpenicillin standard
indicated a purity of 68%.
The 3-o-chlorophenyl-5-methylisoxazole-4-carboxylic acid, from which the acid
chloride was prepared, was obtained by hydrolysis of the ester product of the
reaction between o-chlorobenzohydroxamic chloride and ethyl acetoacetate in
methanolic sodium methoxide. Reaction with thionyl chloride gave the starting
material.
brand name
Cloxapen (GlaxoSmithKline); Tegopen (Apothecon).
Therapeutic Function
Antibacterial
Purification Methods
Purify cloxacillin sodium salt by dissolving it in isoPrOH containing 20% of H2O, and diluting with isoPrOH to a water content of 5% and chilling. Recrystallise it again in this manner. The sodium salt is collected and dried at 40o in air to give the colourless monohydrate. It is soluble in H2O (5%), MeOH, EtOH, pyridine and ethylene glycol. [Doyle et al. J Chem Soc 5838 1963, Naylor et al. Nature 195 1264 1962.] ( ) -Cocaine {ecogonine methyl ester benzoate, 2 -carbomethoxy-3--benzoxytropane, methyl 1R -(exo,exo)]-3-(benzoyloxy)-2-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate}
Properties of Cloxacillin-13C4 SodiuM Salt
Melting point: | 170°C |
storage temp. | 2-8°C |
solubility | H2O: 50 mg/mL, clear, colorless |
form | Solid |
color | White to Off-White |
Water Solubility | Soluble in water |
Stability: | Stable. Incompatible with strong oxidizing agents. Refrigerate. |
CAS DataBase Reference | 642-78-4(CAS DataBase Reference) |
Safety information for Cloxacillin-13C4 SodiuM Salt
Computed Descriptors for Cloxacillin-13C4 SodiuM Salt
Abamectin manufacturer
Syschem (India) Limited
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