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HomeProduct name listCloxacillin-13C4 SodiuM Salt

Cloxacillin-13C4 SodiuM Salt

  • CAS NO.:642-78-4
  • Empirical Formula: C19H19ClN3NaO5S
  • Molecular Weight: 459.88
  • MDL number: MFCD00150735
  • EINECS: 211-390-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 16:48:35
Cloxacillin-13C4 SodiuM Salt Structural

What is Cloxacillin-13C4 SodiuM Salt?

Description

Cloxacillin is a β-lactam antibiotic and a derivative of oxacillin . It is active against clinical isolates of the Gram-positive bacteria S. aureus and S. epidermidis (MICs = 0.004-0.4 and 0.1-0.8 μg/ml, respectively) but not 34 Gram-negative bacteria (MICs = >128 μg/ml for all). Cloxacillin binds to S. aureus penicillin-binding protein 1 (PBP1), PBP2, PBP3, and PBP4 (IC50s = 0.04, 0.12, 0.21, and 2.5 μg/ml, respectively). It also binds to recombinant type Ib penicillinase, as well as P. vulgaris and C. freundii cephalosporinase (Kis = 15, 0.27, and 0.027 μM, respectively). Cloxacillin decreases the number of staphylococci in the mammary gland in a mouse model of acute, but not chronic, mastitis induced by Staphylococcus infection.

Chemical properties

White Crystalline Powder

Originator

Orbenin,Beecham,UK,1962

The Uses of Cloxacillin-13C4 SodiuM Salt

Cloxacillin-13C4 SodiuM Salt is an antibiotic that belongs to the group of the isoxazolylpenicillins. Cloxacillin is used to treat infections caused by species of staphylococci that produce beta-lactamase due to its inhibitory effects on beta-lactamase binding.

The Uses of Cloxacillin-13C4 SodiuM Salt

Cloxacillin-13C4 SodiuM Salt, an antibiotic that belongs to the group of the isoxazolylpenicillins. Cloxacillin is used to treat infections caused by species of staphylococci that produce beta-lac tamase due to its inhibitory effects on beta-lactamase binding.

The Uses of Cloxacillin-13C4 SodiuM Salt

Labelled S-Form of Dropropizine. Cough suppressive phenylpiperazine derivative. Antitussive.

The Uses of Cloxacillin-13C4 SodiuM Salt

Ropivacaine (R675000) metabolite.

What are the applications of Application

Cloxacillin sodium salt is an antibiotic

Definition

ChEBI: Cloxacillin sodium is an organic sodium salt. It contains a cloxacillin(1-).

Manufacturing Process

The reaction between 6-aminopenicillanic acid (6.5 g) and 3-o-chlorophenyl-5- methylisoxazole4-carbonyl chloride (7.66 g) gave the sodium salt of 3-ochlorophenyl-5-methyl-4-isoxazolylpenicillin (9.98 g) as a pale yellow solid. Colorimetric assay with hydroxylamine against a benzylpenicillin standard indicated a purity of 68%.
The 3-o-chlorophenyl-5-methylisoxazole-4-carboxylic acid, from which the acid chloride was prepared, was obtained by hydrolysis of the ester product of the reaction between o-chlorobenzohydroxamic chloride and ethyl acetoacetate in methanolic sodium methoxide. Reaction with thionyl chloride gave the starting material.

brand name

Cloxapen (GlaxoSmithKline); Tegopen (Apothecon).

Therapeutic Function

Antibacterial

Purification Methods

Purify cloxacillin sodium salt by dissolving it in isoPrOH containing 20% of H2O, and diluting with isoPrOH to a water content of 5% and chilling. Recrystallise it again in this manner. The sodium salt is collected and dried at 40o in air to give the colourless monohydrate. It is soluble in H2O (5%), MeOH, EtOH, pyridine and ethylene glycol. [Doyle et al. J Chem Soc 5838 1963, Naylor et al. Nature 195 1264 1962.] ( ) -Cocaine {ecogonine methyl ester benzoate, 2 -carbomethoxy-3--benzoxytropane, methyl 1R -(exo,exo)]-3-(benzoyloxy)-2-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate}

Properties of Cloxacillin-13C4 SodiuM Salt

Melting point: 170°C
storage temp.  2-8°C
solubility  H2O: 50 mg/mL, clear, colorless
form  Solid
color  White to Off-White
Water Solubility  Soluble in water
Stability: Stable. Incompatible with strong oxidizing agents. Refrigerate.
CAS DataBase Reference 642-78-4(CAS DataBase Reference)

Safety information for Cloxacillin-13C4 SodiuM Salt

Computed Descriptors for Cloxacillin-13C4 SodiuM Salt

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