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HomeProduct name listcloprednol

cloprednol

  • CAS NO.:5251-34-3
  • Empirical Formula: C21H25ClO5
  • Molecular Weight: 392.876
  • MDL number: MFCD00200364
  • EINECS: 2260526
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 16:48:35
cloprednol Structural

What is cloprednol?

Originator

Syntestan,Syntex,W. Germany,1980

The Uses of cloprednol

A systematic corticosteroid. Anti-inflammatory.

Definition

ChEBI: Cloprednol is a 21-hydroxy steroid.

Manufacturing Process

A mixture of 5 g of the 21-acetate of 6α-chlorohydrocortisone, 7 g of chloranil and 100 cc of n-amyl alcohol was refluxed for 16 hours, cooled and diluted with ether. The solution was successively washed with water, 5% sodium carbonate solution and water, dried over anhydrous sodium sulfate, filtered and evaporated to dryness under reduced pressure. Chromatographic purification of the residue yielded the 21-acetate of 6-chloro-δ1,4,6- pregnatriene-11β,17α,21-triol-3,20-dione.

Therapeutic Function

Glucocorticoid

Properties of cloprednol

Melting point: >125°C (dec.)
Boiling point: 600.3±55.0 °C(Predicted)
Density  1.40±0.1 g/cm3(Predicted)
storage temp.  -20°C Freezer
solubility  Ethyl Acetate (Slightly), Methanol (Slightly)
form  Solid
pka 12.30±0.70(Predicted)
color  White to Off-White

Safety information for cloprednol

Computed Descriptors for cloprednol

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