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HomeProduct name listDexamethasone 21-phosphate disodium salt

Dexamethasone 21-phosphate disodium salt

Synonym(s):Dexamethasone 21-phosphate disodium salt

  • CAS NO.:2392-39-4
  • Empirical Formula: C22H28FNa2O8P
  • Molecular Weight: 516.4
  • MDL number: MFCD00079105
  • EINECS: 219-243-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
Dexamethasone 21-phosphate disodium salt Structural

What is Dexamethasone 21-phosphate disodium salt?

Chemical properties

White or almost white, very hygroscopic powder.

Originator

Decadron Phosphate,MS and D,US,1959

The Uses of Dexamethasone 21-phosphate disodium salt

Dexamethasone 21-phosphate disodium salt acts as an inducer of apoptosis and inhibitor of the sodium phosphate symporter. It is used in the treatment of emetic effects of cancer therapy and epicondylitis. Further, it serves as an activator of food, medicine, glucocorticoid and anti inflammatory.

The Uses of Dexamethasone 21-phosphate disodium salt

glucocorticoid, antiinflammatory

The Uses of Dexamethasone 21-phosphate disodium salt

Dexamethasone-21-phosphate disodium salt is used in eye and ear preparations and in systemic preparations.

What are the applications of Application

Dexamethasone Sodium Phosphate is an inducer of apoptosis and inhibitor of the sodium phosphate symporter

Definition

ChEBI: An organic sodium salt which is the disodium salt of dexamethasone phosphate.

Manufacturing Process

A solution of bis-triethylamine phosphate was prepared by slowly adding 2.36 ml of 85% phosphoric acid to 20 ml of acetonitrile containing 9.9 ml of triethylamine at 20°C. This solution was added to a stirred solution of 4.70 g of 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,2-dione 21- methanesulfonate and 20 ml of acetonitrile. The mixture was heated under reflux for four hours and then evaporated under reduced pressure to a volume of 12 ml. This mixture was a concentrated solution of 9α-fluoro-11β,17α,21- trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-phosphate triethylamine salt with some inorganic phosphate.
The mixture was cooled, 25 ml of methanol added, and the cooled mixture treated with 33 ml of 1.89 N methanolic sodium methoxide solution. The precipitated inorganic phosphates were removed by suction filtration and washed thoroughly with methanol. The combined filtrates were evaporated under reduced pressure to a volume of 12 ml and treated with 30 ml of methanol. The resulting cloudy solution was clarified by filtration through diatomaceous earth. The volume of the filtrate was brought to 40 ml by the addition of methanol, and 120 ml of ether was added with stirring. The precipitated product, which was 9α-fluoro-11β,17α,21-trihydroxy-16α-methyl1,4-pregnadiene-3,20-dione 21-phosphate sodium salt, was collected by suction filtration, and washed with acetone and then with ether. The weight of the air-dried material was 3.06 g.

brand name

Decadron (Merck); Dexacen (Cent); Dexacort (UCB); Dexair (Pharmafair); Hexadrol (Organon); Maxidex (Alcon).

Therapeutic Function

Glucocorticoid

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by intravenous route: peritonitis, central nervous system, and gastrointestinal changes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of F-, PO,, and Na2O.

Properties of Dexamethasone 21-phosphate disodium salt

Melting point: 233-235 °C
alpha  D +57° (water); D25 +74 ±4° (calcd on water-free and alcohol-free basis, concn of 10 mg/ml): USP XIX, p 124
storage temp.  2-8°C
solubility  H2O: 50 mg/mL, clear, faintly yellow
form  White Powder
color  white to off-white
PH pH(10g/l, 25℃) : 7.5~10.5
Water Solubility  Soluble in water. Slightly soluble in ethanol. Insoluble in dichloromethane.
Merck  13,2960
BRN  6473066
Stability: Hygroscopic
CAS DataBase Reference 2392-39-4(CAS DataBase Reference)
EPA Substance Registry System Dexamethasone disodium phosphate (2392-39-4)

Safety information for Dexamethasone 21-phosphate disodium salt

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P201:Obtain special instructions before use.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for Dexamethasone 21-phosphate disodium salt

InChIKey PLCQGRYPOISRTQ-FCJDYXGNSA-L

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