CLOFEZONE
- CAS NO.:60104-29-2
- Empirical Formula: C33H41ClN4O4
- Molecular Weight: 593.17
- SAFETY DATA SHEET (SDS)
- Update Date: 2022-12-21 16:56:50
What is CLOFEZONE?
Originator
Perclusone,Anphar-Rolland,France,1967
Manufacturing Process
935 g of phenylbutazone are dissolved, with heating to a lukewarm state, in 2.7 liters of acetone containing 20% water, and the mixture is filtered if necessary. 853.5 g of p-chlorophenoxyacetic acid diethylamino ethylamide are dissolved in 300 cc of acetone containing 20% water, and the solution is poured into the phenylbutazone solution. There is slight heating, and the solution clarifies. The salt crystallizes rapidly. Drying is effected on a Buchner funnel and the mixture is washed in 450 cc of acetone containing 20% of water. The 1,702 g of product obtained is recrystallized in 2,450 cc of acetone containing 20% of water and, after drying in an oven at 37°C, 1,585 g (86%) of product are obtained. The product is in the form of a white crystalline powder having a melting point of from 87° to 89°C in the Maquenne block.
Therapeutic Function
Analgesic, Antiinflammator
Properties of CLOFEZONE
pka | pKa 4.5(H2O t unde?ned I unde?ned) (Uncertain) |
Safety information for CLOFEZONE
Computed Descriptors for CLOFEZONE
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