MOFEBUTAZONE
- CAS NO.:2210-63-1
- Empirical Formula: C13H16N2O2
- Molecular Weight: 232.28
- MDL number: MFCD00022559
- EINECS: 218-641-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-19 15:37:50
What is MOFEBUTAZONE?
Originator
Butaphen,Wiedenmann
The Uses of MOFEBUTAZONE
Mofebutazone is an anti-inflammatory drug used on the gastrointestinal and renal tissues.
Definition
ChEBI: A pyrazolidine that is phenylbutazone lacking one of the phenyl substituents. It is used for treatment of joint and muscular pain.
Manufacturing Process
A mixture comprising 108 g of phenyl hydrazine and 216 g of the diethyl ester of n-butylmalonic acid is heated on an oil bath at 170°-180°C for 12 hours. The residue is taken up with water in which an alkaline compound has been dissolved and acetic acid is added to precipitate 4-n-butyl-2-phenylpyrazolidine-3,5-dione. The product is a white crystalline solid having a MP: 103°C. It is soluble in acetone and benzene, soluble in hot condition in methanol and ethanol and insoluble in water.
brand name
Arcobutine;Buta lyseen;Chemiartrol;Clinit;Diadin;Fenartril;Jovapyrin;Mobutazone;Mofasal;Mofesal;Monazone;Monbutina;Monobutina;Monofen;Monomil;Monoprine;Monozon;Mozol;Rheuma-cur;Rheumaorctat;Rivodol;Sodepyrine b 1.
Therapeutic Function
Antirheumatic, Analgesic, Antiinflammatory
World Health Organization (WHO)
Mofebutazone, a pyrazolone with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1962 for the treatment of rheumatic disorders. As it is structurally related to phenylbutazone it is subjected to rigorously restricted indications by some national regulatory authorities. See WHO comment for phenylbutazone.
Clinical Use
Mofebutazone is a nonsteroidal anti-inflammatory drug used as sodium salt for the treatment of mild to moderate pain including inflammatory and degenerative rheumatic disorders and musculoskeletal pain. Mofebutazone can be given by oral, rectal (900–1200 mg/d), or intramuscular administration (650 mg/d).
Properties of MOFEBUTAZONE
Melting point: | 102-103° |
Boiling point: | 374.44°C (rough estimate) |
Density | 1.1099 (rough estimate) |
refractive index | 1.6450 (estimate) |
storage temp. | Room Temperature |
solubility | DMSO (Slightly), Methanol (Sparingly) |
form | Solid |
pka | 5.22±0.10(Predicted) |
color | White to Off-White |
Safety information for MOFEBUTAZONE
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P362:Take off contaminated clothing and wash before reuse. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..… |
Computed Descriptors for MOFEBUTAZONE
New Products
(2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin D Tubulysin G Tubulysin B Diethyl Aluminium Cyanide (1.0 M in Toluene) Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 4-(Benzyloxy)-3-bromophenylacetic Acid 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 4,4-DIFLUOROPIPERIDINE 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE Imeglimin Hydrochloride IH Fuel shell 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (3-Fluoro-4- morpholin-4-yl- phenyl)- carbamic acid methyl ester (S)-4-(azidomethyl) -3-(3-fluoro-4- thiomorpholino phenyl) oxazolidin-2-one Magnesium Trisilicate Lubiprostone Latanoprostene Bunod Flame Retardant Zinc Borate 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
You may like
-
Fuel shell 98%View Details
-
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9 98%View Details
145783-15-9 -
109113-72-6 2-(Chloromethyl)-4-methylquinazoline (2-CMQ) 98%View Details
109113-72-6 -
Hydrogen Gas 98%View Details
-
590-17-0 Bromoacetonitrile 98%View Details
590-17-0 -
151767-02-1 Montelukast Sodium IP/USP 98%View Details
151767-02-1 -
Valacyclovir Hydrochloride IH 98%View Details
124832-27-5 -
2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 98%View Details
142569-70-8