Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listMOFEBUTAZONE

MOFEBUTAZONE

  • CAS NO.:2210-63-1
  • Empirical Formula: C13H16N2O2
  • Molecular Weight: 232.28
  • MDL number: MFCD00022559
  • EINECS: 218-641-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
MOFEBUTAZONE Structural

What is MOFEBUTAZONE?

Originator

Butaphen,Wiedenmann

The Uses of MOFEBUTAZONE

Mofebutazone is an anti-inflammatory drug used on the gastrointestinal and renal tissues.

Definition

ChEBI: A pyrazolidine that is phenylbutazone lacking one of the phenyl substituents. It is used for treatment of joint and muscular pain.

Manufacturing Process

A mixture comprising 108 g of phenyl hydrazine and 216 g of the diethyl ester of n-butylmalonic acid is heated on an oil bath at 170°-180°C for 12 hours. The residue is taken up with water in which an alkaline compound has been dissolved and acetic acid is added to precipitate 4-n-butyl-2-phenylpyrazolidine-3,5-dione. The product is a white crystalline solid having a MP: 103°C. It is soluble in acetone and benzene, soluble in hot condition in methanol and ethanol and insoluble in water.

brand name

Arcobutine;Buta lyseen;Chemiartrol;Clinit;Diadin;Fenartril;Jovapyrin;Mobutazone;Mofasal;Mofesal;Monazone;Monbutina;Monobutina;Monofen;Monomil;Monoprine;Monozon;Mozol;Rheuma-cur;Rheumaorctat;Rivodol;Sodepyrine b 1.

Therapeutic Function

Antirheumatic, Analgesic, Antiinflammatory

World Health Organization (WHO)

Mofebutazone, a pyrazolone with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1962 for the treatment of rheumatic disorders. As it is structurally related to phenylbutazone it is subjected to rigorously restricted indications by some national regulatory authorities. See WHO comment for phenylbutazone.

Clinical Use

Mofebutazone is a nonsteroidal anti-inflammatory drug used as sodium salt for the treatment of mild to moderate pain including inflammatory and degenerative rheumatic disorders and musculoskeletal pain. Mofebutazone can be given by oral, rectal (900–1200 mg/d), or intramuscular administration (650 mg/d).

Properties of MOFEBUTAZONE

Melting point: 102-103°
Boiling point: 374.44°C (rough estimate)
Density  1.1099 (rough estimate)
refractive index  1.6450 (estimate)
storage temp.  Room Temperature
solubility  DMSO (Slightly), Methanol (Sparingly)
form  Solid
pka 5.22±0.10(Predicted)
color  White to Off-White

Safety information for MOFEBUTAZONE

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H332:Acute toxicity,inhalation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P362:Take off contaminated clothing and wash before reuse.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.
P405:Store locked up.
P403+P233:Store in a well-ventilated place. Keep container tightly closed.
P501:Dispose of contents/container to..…

Computed Descriptors for MOFEBUTAZONE

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.