Citrazinic acid

Synonym(s):2,6-Dihydroxyisonicotinic acid;2,6-Dihydroxypyridine-4-carboxylic acid;Citrazinic acid

CAS NO.：99-11-6
Empirical Formula: C6H5NO4
Molecular Weight: 155.11
MDL number: MFCD00006274
EINECS: 202-731-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-15 19:19:13

What is Citrazinic acid?

Chemical properties

yellow powder

The Uses of Citrazinic acid

2,6-Dihydroxypyridine-4-carboxylic acid (citrazinic acid) was used to prepare 2,6-dibromo-4-(hexoxymethyl)pyridine. It was also used to synthesize the derivatives of oxazinones and pyrimidinones.

The Uses of Citrazinic acid

2,6-Dihydroxypyridine-4-carboxylic acid was used to prepare 2,6-dibromo-4-(hexoxymethyl)pyridine. It was also used to synthesize the derivatives of oxazinones and pyrimidinones.

Definition

ChEBI: CITRAZINIC ACID is an aromatic carboxylic acid and a member of pyridines.

Purification Methods

The acid is normally a yellow powder with a greenish shade, but is white when ultra pure and turns blue on long standing. It is insoluble in H2O but slightly soluble in hot HCl and soluble in alkali or carbonate solutions. It is purified by precipitation from alkaline solutions with dilute HCl, and dried in a vacuum over P2O5. The ethyl ester has m 232o (evacuated tube) and a pKa of 4.81 in MeOCH2CH2OH [IR: Pitha Coll Czech Chem Comm 28 1408 1963]. [Beilstein 22/7 V 24.]

Properties of Citrazinic acid

Melting point:	>300 °C(lit.)
Boiling point:	278.88°C (rough estimate)
Density	0.65 g/cm3
refractive index	1.5423 (estimate)
storage temp.	Inert atmosphere,2-8°C
solubility	practically insoluble
pka	2.54±0.20(Predicted)
form	Powder
color	Yellow
PH	3.1-3.5 (100g/l, H2O)(slurry)
Water Solubility	practically insoluble
Merck	14,2325
BRN	383736
CAS DataBase Reference	99-11-6(CAS DataBase Reference)
NIST Chemistry Reference	Isonicotinic acid, 2,6-dihydroxy-,(99-11-6)
EPA Substance Registry System	Citrazinic acid (99-11-6)

Safety information for Citrazinic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.