cis-Octahydro-1H-isoindole hydrochloride
- CAS NO.:161829-92-1
- Empirical Formula: C8H16ClN
- Molecular Weight: 161.67234
- MDL number: MFCD09026400
- EINECS: 1806241-263-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-20 11:35:54
What is cis-Octahydro-1H-isoindole hydrochloride?
Description
Cis-Octahydro-1H-isoindole hydrochloride is an important intermediate in the synthesis of mitiglinide which is a new oral hypoglycemic drug for the treatment of type II diabetes for the first marked in Japan
Preparation
Phthalimide was used as raw material to react with KOH. Benzyl bromide was subsequently added to the solution to obtain the N-benzylphthalimide. The addition of lithium tetrahydroaluminum, reducing compound N-benzylphthalimide, yields N-benzyldihydroisoindole. Finally, cis-Octahydro-1H-isoindole hydrochlorid is obtained by Pd/C catalysis and reduction
Properties of cis-Octahydro-1H-isoindole hydrochloride
Melting point: | 121-123 °C |
storage temp. | Sealed in dry,Room Temperature |
InChI | InChI=1/C8H15N.ClH/c1-2-4-8-6-9-5-7(8)3-1;/h7-9H,1-6H2;1H/t7-,8+; |
Safety information for cis-Octahydro-1H-isoindole hydrochloride
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P233:Keep container tightly closed. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304:IF INHALED: P312:Call a POISON CENTER or doctor/physician if you feel unwell. P321:Specific treatment (see … on this label). P340:Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362:Take off contaminated clothing and wash before reuse. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P403:Store in a well-ventilated place. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..… |
Computed Descriptors for cis-Octahydro-1H-isoindole hydrochloride
InChIKey | CLQIZUYXKFTUEB-KVZVIFLMNA-N |
SMILES | [H][C@]12CCCC[C@@]1([H])CNC2.Cl |&1:1,6,r| |
Related products of tetrahydrofuran
1,1'-Carbonyldiimidazole
Pentamethyldiethylenetriamine
Benzamidine hydrochloride
Chromium nicotinate
Terbinafine
DICAPRYLYL CARBONATE
Ethylene thiourea
Pyridoxamine dihydrochloride
You may like
-
Cis-hexahydroisoindole CAS 161829-92-1View Details
161829-92-1 -
77-92-9 99%View Details
77-92-9 -
77-92-9 99%View Details
77-92-9 -
8000-27-9 CEDAR WOOD OIL 99%View Details
8000-27-9 -
AMMONIUM DICHROMATE 7789-09-5 99%View Details
7789-09-5 -
77-78-1 DIMETHYL SULPHATE 99%View Details
77-78-1 -
7778-80-5 POTASSIUM SULPHATE 99%View Details
7778-80-5 -
95-54-5 99%View Details
95-54-5
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.