cis-Octahydro-1H-isoindole hydrochloride

CAS NO.：161829-92-1
Empirical Formula: C8H16ClN
Molecular Weight: 161.67234
MDL number: MFCD09026400
EINECS: 1806241-263-5
SAFETY DATA SHEET (SDS)
Update Date: 2023-09-20 11:35:54

What is cis-Octahydro-1H-isoindole hydrochloride?

Description

Cis-Octahydro-1H-isoindole hydrochloride is an important intermediate in the synthesis of mitiglinide which is a new oral hypoglycemic drug for the treatment of type II diabetes for the first marked in Japan

Preparation

Phthalimide was used as raw material to react with KOH. Benzyl bromide was subsequently added to the solution to obtain the N-benzylphthalimide. The addition of lithium tetrahydroaluminum, reducing compound N-benzylphthalimide, yields N-benzyldihydroisoindole. Finally, cis-Octahydro-1H-isoindole hydrochlorid is obtained by Pd/C catalysis and reduction

Properties of cis-Octahydro-1H-isoindole hydrochloride

Melting point:	121-123 °C
storage temp.	Sealed in dry,Room Temperature
InChI	InChI=1/C8H15N.ClH/c1-2-4-8-6-9-5-7(8)3-1;/h7-9H,1-6H2;1H/t7-,8+;

Safety information for cis-Octahydro-1H-isoindole hydrochloride

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P233:Keep container tightly closed. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304:IF INHALED: P312:Call a POISON CENTER or doctor/physician if you feel unwell. P321:Specific treatment (see … on this label). P340:Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362:Take off contaminated clothing and wash before reuse. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P403:Store in a well-ventilated place. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..…