Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listChromium nicotinate

Chromium nicotinate

  • CAS NO.:64452-96-6
  • Empirical Formula: C6H5CrNO2
  • Molecular Weight: 175.11
  • MDL number: MFCD00186328
  • EINECS: 456-568-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-31 18:15:48
Chromium nicotinate Structural

What is Chromium nicotinate?

Absorption

Chromium compounds are both absorbed by the lung and the gastrointestinal tract. Oral absorption of chromium compounds in humans can range between 0.5% and 10%, with the hexavalent (VI) chromium more easily absorbed than the trivalent (III) form . Absorption of chromium from the intestinal tract is low, ranging from less than 0.4% to 2.5% of the amount consumed . Vitamin C and the vitamin B niacin is reported to enhance chromium absorption .
Most hexavalent Cr (VI) undergoes partial intragastric reduction to Cr (III) upon absorption, which is an action mainly mediated by sulfhydryl groups of amino acids . Cr (VI) readily penetrates cell membranes and chromium can be found in both erythrocytes and plasma after gastrointestinal absorption of Cr (IV). In comparison, the presence of chromium is limited to the plasma as Cr (III) displays poor cell membrane penetration . Once transported through the cell membrane, Cr (VI) is rapidly reduced to Cr (III), which subsequently binds to macromolecules or conjugate with proteins. Cr (III) may be bound to transferrin or other plasma proteins, or as complexes, such as glucose tolerance factor (GTF).

Toxicity

Oral LD50 for Cr (VI) is 135 - 175 mg/kg in mouse and 46 - 113 mg/kg in rat . Oral LD50 for Cr (III) in rat is >2000 mg/kg . LD50 of chromium (III) oxide in rats is reported to be > 5g/kg . Other LD50 values reported for rats include: 3.5 g/kg (CI 3.19-3.79 g/kg) for chromium sulphate; 11.3 g/kg for chromium (III) acetate; 3.3 g/kg for chromium nitrate; and 1.5 g/kg for chromium nitrate nonahydrate .
Acute overdose of chromium is rare and seriously detrimental effects of hexavalent chromium are primarily the result of chronic low-level exposure . In case of overdose with minimal toxicity following acute ingestion, treatment should be symptomatic and supportive . There is no known antidote for chromium toxicity.
Hexavalent chromium is a Class A carcinogen by the inhalation route of exposure and Class D by the oral route . The oral lethal dose in humans has been estimated to be 1-3 g of Cr (VI); oral toxicity most likely involves gastrointestinal bleeding rather than systemic toxicity . Chronic exposure may cause damage to the following organs: kidneys, lungs, liver, upper respiratory tract . Soluble chromium VI compounds are human carcinogens. Hexavalent chromium compounds were mutagenic in bacteria assays and caused chromosome aberrations in mammalian cells. There have been associations of increased frequencies of chromosome aberrations in lymphocytes from chromate production workers . In human cells in vitro, Cr (VI) caused chromosomal aberrations, sister chromatid exchanges and oxidative DNA damage .

Chemical properties

gray, fine crystalline powder, stable, slightly soluble in water, insoluble in ethanol.

The Uses of Chromium nicotinate

Chromium nicotinate is an organic chromium chelate formed by nicotinic acid and trivalent chromium ions. It can be used as medicine, health food and feed additive. Also Chromium nicotinate can be used as a functional factor of medicine and health care products: hypoglycemic and lipid-lowering, weight loss supplement, muscle strengthening, and immunity enhancement.

The Uses of Chromium nicotinate

Chromium nicotinate was widely used in food health care and feed additives.

Indications

Indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN), to maintain chromium serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms .

Pharmacokinetics

Trivalent chromium is part of glucose tolerance factor, an essential activator of insulin-mediated reactions. Chromium helps to maintain normal glucose metabolism and peripheral nerve function. Chromium increases insulin binding to cells, increases insulin receptor density and activates insulin receptor kinase leading to enhanced insulin sensitivity . In chromium deficiency, intravenous administration of chromium resulted in normalization of the glucose tolerance curve from the diabetic-like curve typical of chromium deficiency .

Metabolism

The metabolism of Cr (VI) involves reduction by small molecules and enzyme systems to generate Cr (III) and reactive intermediates. During this process, free radicals can be generated, which is thought to induce damage of cellular components and cause toxicity of chromium . The metabolites bind to cellular constituents .

Properties of Chromium nicotinate

CAS DataBase Reference 64452-96-6(CAS DataBase Reference)

Safety information for Chromium nicotinate

Computed Descriptors for Chromium nicotinate

Abamectin manufacturer

Amsal Chem Private Limited

1Y
Phone:+91-2222050500
product: 64452-96-6 99%
Inquiry

SLN Pharmachem

1Y
Phone:+91-8655040421
Whatsapp: +91-8655040421
product: Chromium polynicotinate 98%
Inquiry

Pure Ingredients

1Y
Phone:+91-9925011306
Whatsapp: +91-9925011306
product: Chromium polynicotinate 64452-96-6 98%
Inquiry

Oceanic Laboratories Pvt Ltd

1Y
Phone:+919673916010
Whatsapp: +91-9673916010
product: 64452-96-6 Chromium polynicotinate 98%
Inquiry

Resonance Specialties Limited

1Y
Phone:+912268572824
product: 64452-96-6 98%
Inquiry

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.