Cibenzoline succinate
Synonym(s):2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole succinate;Cibenol;Cipralan;Exacor
- CAS NO.：100678-32-8
- Empirical Formula: C18H18N2.C4H6O4
- Molecular Weight: 380.44
- MDL number: MFCD00941423
- EINECS: 634-471-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:43:56
What is Cibenzoline succinate?
The Uses of Cibenzoline succinate
Cibenzoline Succinate acts as a highly active class I antiarrhythmic agent.
The Uses of Cibenzoline succinate
Cardiac depressant (anti-arrhythmic).
Definition
ChEBI: Cibenzoline succinate is a diarylmethane.
General Description
Cibenzoline also called (±)-2-(2,2-diphenylcyclopropyl)-2-imidazoline succinate, is generally used in stereo combination of R(+) and S(?) forms. It also exhibits anticholinergic activity.. Cibenzoline is known to improve left ventricular diastolic dysfunction by reducing left ventricular pressure gradient.
Biochem/physiol Actions
Cibenzoline is a class IA antiarrhythmic drug. Cibenzoline (μM concentrations) blocks ATP-sensitive K channels in heart and pancreatic cells. Cibenzoline interacts with the channel pore-forming subunit of the K(ATP) channel (Kir6.2) from the cytoplasmic side. Cibenzoline also inhibits the delayed rectifier K current [I(Kr)] in sino-atrial node cells.
Properties of Cibenzoline succinate
| Melting point: | 165° |
| storage temp. | 2-8°C |
| solubility | H2O: ≥5mg/mL |
| form | solid |
| color | white to off-white |
| Stability: | Light Sensitive |
Safety information for Cibenzoline succinate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for Cibenzoline succinate
New Products
Tert-butyl bis(2-chloroethyl)carbamate 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid DIETHYL AMINOMALONATE HYDROCHLORIDE 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) N-METHYL INDAZOLE-3-CARBOXYLIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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