Tolazoline hydrochloride
Synonym(s):2-Benzyl-2-imidazoline;2-Benzyl-2-imidazoline hydrochloride
- CAS NO.:59-97-2
- Empirical Formula: C10H13ClN2
- Molecular Weight: 196.68
- MDL number: MFCD00012693
- EINECS: 200-447-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 14:32:37
What is Tolazoline hydrochloride?
Chemical properties
Pale Yellow Crystalline Solid
Originator
Priscoline,Ciba,US,1948
The Uses of Tolazoline hydrochloride
a-adrenergic antagonist. A peripheral vasodilator
The Uses of Tolazoline hydrochloride
Αn α-adrenergic antagonist. A peripheral vasodilator.
The Uses of Tolazoline hydrochloride
adrenergic blocker
What are the applications of Application
Tolazoline Hydrochloride is a peripheral vasodilator
Definition
ChEBI: Tolazoline hydrochloride is a member of benzenes.
Manufacturing Process
The phenyl-acetiminoether hydrochloride of the formula from 12 parts of benzylcyanide and ethanol and HCl is mixed with 8 parts of ethylenediamine hydrate which has been diluted with little alcohol, whereby the crystals go into solution. The whole is then heated on the water-bath until the ammonia odor has disappeared, cooled, concentrated caustic potash solution added, and the separated oil extracted with ether. The solution is dried with potassium carbonate and potassium hydroxide. After evaporation a pale oil is left which distills at 147°C under a pressure of 9 mm and which solidifies in the condenser to a white crystalline mass. The yield amounts to 90% of the theory. The hydrochloride melts at 168° to 170°C.
brand name
Tolazoline is INN and BAN.
Therapeutic Function
Vasodilator
Safety Profile
Poison by ingestion, intravenous, and intraperitoneal routes. Human systemic effects by intravenous route: change in heart rate, sweating, ulceration or bleeding from duodeum, ulceration or bleeding from small intestine, unspecified vascular effects. When heated to decomposition it emits very toxic fumes of NO, and HCl.
Veterinary Drugs and Treatments
flipping of lips); piloerection;
clear lacrimal & nasal discharge; muscle fasciculations;
apprehensiveness
Uses/Indications
Tolazoline is approved and indicated for the reversal of effects associated
with xylazine in horses. It has also been used for this purpose
in a variety of other species as well, but less safety and efficacy data
is available.
In humans, the primary uses for tolazoline are: treatment of persistent
pulmonary hypertension in newborns, adjunctive treatment
and diagnosis
Properties of Tolazoline hydrochloride
Melting point: | 172-176 °C |
storage temp. | Inert atmosphere,Room Temperature |
solubility | DMSO (Slightly, Heated), Methanol (Slightly) |
form | Crystalline Powder |
color | White to almost white |
Sensitive | Hygroscopic |
Merck | 14,9506 |
Stability: | Hygroscopic |
CAS DataBase Reference | 59-97-2(CAS DataBase Reference) |
EPA Substance Registry System | Tolazoline hydrochloride (59-97-2) |
Safety information for Tolazoline hydrochloride
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Tolazoline hydrochloride
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