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HomeProduct name listTolazoline hydrochloride

Tolazoline hydrochloride

Synonym(s):2-Benzyl-2-imidazoline;2-Benzyl-2-imidazoline hydrochloride

  • CAS NO.:59-97-2
  • Empirical Formula: C10H13ClN2
  • Molecular Weight: 196.68
  • MDL number: MFCD00012693
  • EINECS: 200-447-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-18 14:07:02
Tolazoline hydrochloride Structural

What is Tolazoline hydrochloride?

Chemical properties

Pale Yellow Crystalline Solid

Originator

Priscoline,Ciba,US,1948

The Uses of Tolazoline hydrochloride

a-adrenergic antagonist. A peripheral vasodilator

The Uses of Tolazoline hydrochloride

Αn α-adrenergic antagonist. A peripheral vasodilator.

The Uses of Tolazoline hydrochloride

adrenergic blocker

What are the applications of Application

Tolazoline Hydrochloride is a peripheral vasodilator

Definition

ChEBI: Tolazoline hydrochloride is a member of benzenes.

Manufacturing Process

The phenyl-acetiminoether hydrochloride of the formula from 12 parts of benzylcyanide and ethanol and HCl is mixed with 8 parts of ethylenediamine hydrate which has been diluted with little alcohol, whereby the crystals go into solution. The whole is then heated on the water-bath until the ammonia odor has disappeared, cooled, concentrated caustic potash solution added, and the separated oil extracted with ether. The solution is dried with potassium carbonate and potassium hydroxide. After evaporation a pale oil is left which distills at 147°C under a pressure of 9 mm and which solidifies in the condenser to a white crystalline mass. The yield amounts to 90% of the theory. The hydrochloride melts at 168° to 170°C.

brand name

Tolazoline is INN and BAN.

Therapeutic Function

Vasodilator

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Human systemic effects by intravenous route: change in heart rate, sweating, ulceration or bleeding from duodeum, ulceration or bleeding from small intestine, unspecified vascular effects. When heated to decomposition it emits very toxic fumes of NO, and HCl.

Veterinary Drugs and Treatments

flipping of lips); piloerection; clear lacrimal & nasal discharge; muscle fasciculations; apprehensiveness Uses/Indications Tolazoline is approved and indicated for the reversal of effects associated with xylazine in horses. It has also been used for this purpose in a variety of other species as well, but less safety and efficacy data is available.
In humans, the primary uses for tolazoline are: treatment of persistent pulmonary hypertension in newborns, adjunctive treatment and diagnosis

Properties of Tolazoline hydrochloride

Melting point: 172-176 °C
storage temp.  Inert atmosphere,Room Temperature
solubility  DMSO (Slightly, Heated), Methanol (Slightly)
form  Crystalline Powder
color  White to almost white
Sensitive  Hygroscopic
Merck  14,9506
Stability: Hygroscopic
CAS DataBase Reference 59-97-2(CAS DataBase Reference)
EPA Substance Registry System Tolazoline hydrochloride (59-97-2)

Safety information for Tolazoline hydrochloride

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Tolazoline hydrochloride

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