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HomeProduct name listOxymetazoline hydrochloride

Oxymetazoline hydrochloride

Synonym(s):2-(3-Hydroxy-2,6-dimethyl-4-t-butylbenzyl)-2-imidazoline hydrochloride;Oxymetazoline hydrochloride

  • CAS NO.:2315-02-8
  • Empirical Formula: C16H25ClN2O
  • Molecular Weight: 296.84
  • MDL number: MFCD00797520
  • EINECS: 219-015-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-05-21 21:51:03
Oxymetazoline hydrochloride Structural

What is Oxymetazoline hydrochloride?

Chemical properties

Off-White Solid

Originator

Nasivin,Merck,W. Germany ,1961

The Uses of Oxymetazoline hydrochloride

Oxymetazoline hydrochloride is an α1-AR and α2-AR adrenergic receptor agonist and used as Vasoconstrictor, a nasal decongestant.

The Uses of Oxymetazoline hydrochloride

muscle relaxant (smooth), cerebral vasodilator

The Uses of Oxymetazoline hydrochloride

Vasoconstrictor, used as a nasal decongestant. An ingredient of Drixin.

What are the applications of Application

Oxymetazoline Hydrochloride is is an α1-AR and α2-AR adrenergic receptor agonist.

Definition

ChEBI: A hydrochloride salt resulting from the reaction of equimolar quantities of oxymetazoline and hydrogen chloride. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used to relieve nasal con estion.

Manufacturing Process

10 grams 2,6-dimethyl-3-hydroxy-4-tertiary butylbenzylcyanide (produced by chloromethylation of 2,4-dimethyl-6-tertiary butyl-phenol with formaldehyde and HCl and conversion of the substituted benzyl chloride with NaCN; crystals, from alcohol, melting at 135° to 137°C) and 10.7 grams ethylenediaminemono-p-toluenesulfonate are heated in an oil bath to approximately 235°C for 1? hours, whereby ammonia is evolved. The free base is obtained from the p-toluene-sulfonic acid imidazoline salt which is difficultly soluble in water, by conversion with 50 cc of a 10% NaOH solution. Said base is recrystallized from benzene, and 7.5 grams (62% of the theoretical yield) 2-(2',6'-dimethyl3'-hydroxy-4'-tertiary butylbenzyl)-2-imidazoline, MP 180° to 182°C, are obtained.
By dissolving the free base in an ethyl alcohol solution of hydrochloric acid and adding ether, the hydrochloride can be produced in the usual manner. Said hydrochloride melts, when recrystallized from alcoholic ether, at 300° to 303°C and is decomposed

brand name

Ocuclear (Schering-Plough); Visine (Pfizer).

Therapeutic Function

Nasal decongestant

Biological Activity

Partial α 2A adrenoceptor agonist and α 1A agonist. Agonist/antagonist activity at 5-HT receptors.

Properties of Oxymetazoline hydrochloride

Melting point: approximate 300℃ (dec.)
storage temp.  Store at RT
solubility  H2O: soluble
form  solid
color  white
PH pH (50g/L, 25℃) : 4.0~6.5
Water Solubility  Soluble to 50 mM in water
Stability: Toxic
CAS DataBase Reference 2315-02-8(CAS DataBase Reference)

Safety information for Oxymetazoline hydrochloride

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H318:Serious eye damage/eye irritation
H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Oxymetazoline hydrochloride

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