Oxymetazoline hydrochloride
Synonym(s):2-(3-Hydroxy-2,6-dimethyl-4-t-butylbenzyl)-2-imidazoline hydrochloride;Oxymetazoline hydrochloride
- CAS NO.:2315-02-8
- Empirical Formula: C16H25ClN2O
- Molecular Weight: 296.84
- MDL number: MFCD00797520
- EINECS: 219-015-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-21 21:51:03
What is Oxymetazoline hydrochloride?
Chemical properties
Off-White Solid
Originator
Nasivin,Merck,W. Germany ,1961
The Uses of Oxymetazoline hydrochloride
Oxymetazoline hydrochloride is an α1-AR and α2-AR adrenergic receptor agonist and used as Vasoconstrictor, a nasal decongestant.
The Uses of Oxymetazoline hydrochloride
muscle relaxant (smooth), cerebral vasodilator
The Uses of Oxymetazoline hydrochloride
Vasoconstrictor, used as a nasal decongestant. An ingredient of Drixin.
What are the applications of Application
Oxymetazoline Hydrochloride is is an α1-AR and α2-AR adrenergic receptor agonist.
Definition
ChEBI: A hydrochloride salt resulting from the reaction of equimolar quantities of oxymetazoline and hydrogen chloride. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used to relieve nasal con estion.
Manufacturing Process
10 grams 2,6-dimethyl-3-hydroxy-4-tertiary butylbenzylcyanide (produced by chloromethylation of 2,4-dimethyl-6-tertiary butyl-phenol with formaldehyde and HCl and conversion of the substituted benzyl chloride with NaCN; crystals, from alcohol, melting at 135° to 137°C) and 10.7 grams ethylenediaminemono-p-toluenesulfonate are heated in an oil bath to approximately 235°C for 1? hours, whereby ammonia is evolved. The free base is obtained from the p-toluene-sulfonic acid imidazoline salt which is difficultly soluble in water, by conversion with 50 cc of a 10% NaOH solution. Said base is recrystallized from benzene, and 7.5 grams (62% of the theoretical yield) 2-(2',6'-dimethyl3'-hydroxy-4'-tertiary butylbenzyl)-2-imidazoline, MP 180° to 182°C, are obtained.
By dissolving the free base in an ethyl alcohol solution of hydrochloric acid and adding ether, the hydrochloride can be produced in the usual manner. Said hydrochloride melts, when recrystallized from alcoholic ether, at 300° to 303°C and is decomposed
brand name
Ocuclear (Schering-Plough); Visine (Pfizer).
Therapeutic Function
Nasal decongestant
Biological Activity
Partial α 2A adrenoceptor agonist and α 1A agonist. Agonist/antagonist activity at 5-HT receptors.
Properties of Oxymetazoline hydrochloride
Melting point: | approximate 300℃ (dec.) |
storage temp. | Store at RT |
solubility | H2O: soluble |
form | solid |
color | white |
PH | pH (50g/L, 25℃) : 4.0~6.5 |
Water Solubility | Soluble to 50 mM in water |
Stability: | Toxic |
CAS DataBase Reference | 2315-02-8(CAS DataBase Reference) |
Safety information for Oxymetazoline hydrochloride
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H318:Serious eye damage/eye irritation H412:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Oxymetazoline hydrochloride
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