Choline bicarbonate

Synonym(s):2-Hydroxyethyl)trimethylammonium bicarbonate

CAS NO.：78-73-9
Empirical Formula: C6H15NO4
Molecular Weight: 165.19
MDL number: MFCD00031689
EINECS: 201-137-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-04-22 18:05:02

What is Choline bicarbonate?

Chemical properties

Colorless liquid.Miscible with water.

The Uses of Choline bicarbonate

Choline Bicarbonate is compound is used for protein delivery.

The Uses of Choline bicarbonate

Choline, a water soluble essential nutrient, is used by the body to make phosphatidylcholine phosphatides and neurotransmitter such as acetylcholine. Choline is used to study a wide range of biological processes from stem cell development to neurological disease studies. Also, An alkaline intermediate useful for preparing salts.

Reactions

[1CA:3PE] - (1:2) Choline 3-Pentenoate Synthesis
Chemical reactions in the synthesis of [1CA:3PE].
An oil bath was heated to approximately 60°C and the stirrer on the hot plate was adjusted to 410 RPM. 3.5022g of 3-Pentenoic acid (MW: 100.12g/mol) were weighed and placed in a 500 mL RBF. 3.6254g of Choline Bicarbonate (MW: 165.19g/mol) were weighed and added to the RBF in a drop-wise manner using a glass Pasteur pipette. Less than 1 mL of milli-Q water was used to rinse the master pipette and weighing materials, the milli-Q was then added to the RBF. The mixture was left stirring on heat overnight for approximately 24 hours. The mixture was then placed on the rotary-evaporator and set to 15 mbar for just over 1 hour in order to evaporate any remaining solvents. The mass of the final product was weighed and noted; 4.5891g of [1CA:3PE] were obtained. The solution was then placed in the vacuum oven set at 60°C for over 48 hours with the top left off. Time sensitivity during this step was not as imperative as other steps since the purpose of this step was to dry out any remaining solvents or water in the IL. Once removed from the vacuum oven, the solution was reweighed and an NMR was obtained for characterization purposes. The final mass of [1CA:3PE] being 4.4934g, resulting in a total percent yield of 86.74%. 1H NMR (400 MHz, DMSO) δ 9.47 (s, 1H), 5.52 (dtd, J = 14.0, 7.0, 1.8 Hz, 2H), 5.37 (dq, J = 13.3, 6.3 Hz, 2H), 3.84 (dq, J = 5.8, 2.7 Hz, 2H), 3.44 (dd, J = 6.1, 3.9 Hz, 2H), 3.14 (s, 9H), 2.80 (d, J = 7.0 Hz, 4H), 1.61 (dd, J = 6.4, 1.8 Hz, 6H).
[1] GALLOWAY J D. The Synthesis and Characterization of Ionic Liquids using Nitrogen-Based Cations for Transdermal Delivery[C]. 2022.

Hazard

Choline bicarbonate can cause skin and eye irritation, as well as potential respiratory irritation.

Biochem/physiol Actions

Acyl group acceptor

Properties of Choline bicarbonate

Density	1.17 g/mL at 25 °C (lit.)
vapor pressure	23.904hPa at 25℃
refractive index	n20/D 1.45
storage temp.	2-8°C
solubility	Methanol (Sparingly), Water (Soluble)
form	Colourless Solution
Water Solubility	750g/L at 20℃
CAS DataBase Reference	78-73-9(CAS DataBase Reference)
EPA Substance Registry System	Choline carbonate (1:1) (78-73-9)

Safety information for Choline bicarbonate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.