Chlorophacinone

Description

Chlorophacinone is produced by condensation of 1- phenyl-1-(4-chlorophenyl) acetone with dimethyl phthalate in the presence of sodium methoxide (31).
This compound was introduced in 1961 and is now widely used in Europe, the United States, and elsewhere. It is used in baits against norway rats at a concentration of 0.005–0.01%. Bait containing 0.025% chlorophacinone gave a complete kill of house mice after a 7-d feeding period but, in other tests, survivors were recorded following 10 and 21 days of feeding (5). Chlorophacinone acts as an uncoupler of oxidative phosphorylation as well as an anticoagulant (32), which is unusual among this group of compounds.

Chemical properties

Chlorophacinone is a highly toxic crystalline solid.

The Uses of Chlorophacinone

Chlorophacinone (CPN) is an anticoagulant rodenticide widely used to control rodent infestations.

The Uses of Chlorophacinone

Anticoagulant rodenticide.

Definition

ChEBI: Chlorophacinone is a diarylmethane and a beta-triketone.

General Description

Crystals. Commercially available as oil concentrate and as dust concentrate. Used as an anticoagulant rodenticide. Chronic acting, multiple dose rodenticide.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Fire may produce irritating or poisonous gases.

Health Hazard

Chlorphacinon is highly toxic orally and by skin absorption. The probable oral lethal dose for humans is less than 5 mg/kg to 50 mg/kg, or between a taste (less than 7 drops) and 1 teaspoonful for a 150 lb. (70 kg) person.

Health Hazard

Highly toxic anticoagulant rodenticide; lowchlorine content but highly toxic; exhibitsacute, delayed, and chronic poisoning;symptoms include bleeding of nose andgum, blood in cough, urine, and stool,abdominal pain and hemorrhage; can beabsorbed through skin causing systemicpoisoning; ingestion of 1–2 g is estimatedto be fatal dose for adult human; U.S. EPAlisted extremely hazardous substance.
LD50 oral (rat): ～2 mg/kg
LD50 oral (mouse): ～1 mg/kg
LD50 oral (rabbit): 50 mg/kg
LD50 skin (rabbit): 200 mg/kg.

Fire Hazard

(Non-Specific -- Coumarin Derivative Pesticide, Solid, n.o.s.) Fire may produce irriating or poisonous gases. Runoff from fire control water may give off poisonous gases. Runoff from fire control or dilution water may cause pollution. When heated Chlorphacinon emits toxic fumes of chlorides.

Agricultural Uses

Rodenticide: This material is an anticoagulant rodenticide used around livestock and also on crops such as artichokes. Some brands are labeled for use indoors and outdoors for the control of mice, rats, moles, muskrats, voles and vampire bats. Not approved for use in EU countries. Registered for use in the U.S. There are 24 global suppliers.

Trade name

AFNOR®; CAID®; DELTA®; DRAT RAT BAIT®; ENDORATS®; LIPHADIONE®; LM 91®; MICROZUL®; MURIOL®; PARTOX®[C]; QUICK®; RAMUCIDE®; RANAC®; RATOMET®; RAVIAC®; ROZOL®[C]; TOPITOX®

Safety Profile

Poison by ingestion and skin contact. Human systemic effects by ingestion: vascular changes. A pesticide. When heated to decomposition it emits toxic fumes of Cl-.

Potential Exposure

Agricultural Chemical. This material is an anticoagulant rodenticide. A potential danger to those involved in its manufacture, formulation, and application are at risk.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 minutes, occasionally lifting upper and lower lids. Seekmedical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.

storage

Color Code—Green: General storage may be used.Prior to working with this chemical you should be trainedon its proper handling and storage. Store in tightly closedcontainers in a cool, well-ventilated area.

Shipping

UN3027 Coumarin derivative pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Waste Disposal

Incineration at high temperature with effluent gas scrubbing.