Chlorophacinone SDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifier
- Product name： Chlorophacinone
- CAS： 3691-35-8
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses： For R&D use only. Not for medicinal, household or other use.
- Uses advised against： none
Company Identification
- Company：Chemicalbook.in
- Address：5 vasavi Layout Basaveswara Nilayam Pragathi Nagar Hyderabad, India -500090
- Telephone：+91 9550333722
SECTION 2: Hazards identification
Classification of the substance or mixture
Acute toxicity - Category 1, Oral
Acute toxicity - Category 1, Dermal
Acute toxicity - Category 1, Inhalation
Specific target organ toxicity – repeated exposure, Category 1
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
Reproductive toxicity, Category 1B
GHS label elements, including precautionary statements
-
Pictogram(s)
- Signal word Danger
H300 Fatal if swallowed
H310 Fatal in contact with skin
H330 Fatal if inhaled
H372 Causes damage to organs through prolonged or repeated exposure
H410 Very toxic to aquatic life with long lasting effects
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P262 Do not get in eyes, on skin, or on clothing.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P284 [In case of inadequate ventilation] wear respiratory protection.
P273 Avoid release to the environment.
P203 Obtain, read and follow all safety instructions before use.
P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P320 Specific treatment is urgent (see ... on this label).
P319 Get medical help if you feel unwell.
P391 Collect spillage.
P318 IF exposed or concerned, get medical advice.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
Substance
- Chemical name: Chlorophacinone
- Common names and synonyms: Chlorophacinone
- CAS number: 3691-35-8
- EC number: 223-003-0
- Concentration: 100%
SECTION 4: First aid measures
Description of necessary first-aid measures
Refer immediately for medical attention.
Wear protective gloves when administering first aid. Remove contaminated clothes. See Notes. Rinse and then wash skin with water and soap. Refer immediately for medical attention.
Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.
Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention.
Most important symptoms/effects, acute and delayed
Chlorophacinone is highly toxic orally and by skin absorption. The probable oral lethal dose for humans is less than 5 mg/kg to 50 mg/kg, or between a taste (less than 7 drops) and 1 teaspoonful for a 150 lb. (70 kg) person. (EPA, 1998)
Indication of immediate medical attention and special treatment needed, if necessary
Human exposure to second-generation and indandione anticoagulants produces symptoms consistent with anticoagulation effects (e.g., hematomas, hematemesis, hematuria, easy bruisability). Treatment of cases of exposure, particularly of substantial and repeated exposure, may require vitamin K1 therapy and monitoring of prothrombin times for periods of many months.
SECTION 5: Firefighting measures
Suitable extinguishing media
Wear self contained breathing apparatus for fire fighting, if necessary.
Specific hazards arising from the chemical
Non-Specific -- Coumarin Derivative Pesticide, Solid, n.o.s.) Fire may produce irriating or poisonous gases. Runoff from fire control water may give off poisonous gases. Runoff from fire control or dilution water may cause pollution. When heated it emits toxic fumes of chlorides. (EPA, 1998)
Special protective actions for fire-fighters
Use powder, water spray, foam, carbon dioxide.
SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Environmental precautions
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Methods and materials for containment and cleaning up
Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe ares. Avoid breathing dust.
SECTION 7: Handling and storage
Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Well closed. Store in an area without drain or sewer access.Keep container tightly closed in a dry and well-ventilated place.
SECTION 8: Exposure controls/personal protection
Control parameters
no data available
no data available
Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
Individual protection measures, such as personal protective equipment (PPE)
Wear face shield or eye protection in combination with breathing protection if powder.
Protective gloves. Protective clothing.
Use closed system.
no data available
SECTION 9: Physical and chemical properties and safety characteristics
-
Physical state：
Crystals. Commercially available as oil concentrate and as dust concentrate. Used as an anticoagulant rodenticide. Chronic acting, multiple dose rodenticide. (EPA, 1998)
-
Colour：
Pale yellow crystals
-
Odour：
Odorless
-
Melting point/freezing point：
140-144°C
-
Boiling point or initial boiling point and boiling range：
555.5°C at 760 mmHg
-
Flammability：
Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
-
Lower and upper explosion limit/flammability limit：
no data available
-
Flash point：
>100°C
-
Auto-ignition temperature：
no data available
-
Decomposition temperature：
no data available
-
pH：
no data available
-
Kinematic viscosity：
no data available
-
Solubility：
In water, 100 mg/L at 20 deg C
-
Partition coefficient n-octanol/water：
log Kow at 23 deg C: 3.08 (pH 4), 2.42 (pH 7), 2.57 (pH 9)
-
Vapour pressure：
1X10-4 mPa /7.5X10-10 mm Hg/ at 25 deg C
-
Density and/or relative density：
1.342g/cm3
-
Relative vapour density：
no data available
-
Particle characteristics：
no data available
SECTION 10: Stability and reactivity
Reactivity
Decomposes on heating. This produces toxic and corrosive fumes including hydrogen chloride.
Chemical stability
Very stable and resistant to weathering.
Possibility of hazardous reactions
Not flammable or combustible.Fire may produce irritating or poisonous gases.
Conditions to avoid
no data available
Incompatible materials
no data available
Hazardous decomposition products
When heated to decomposition it emits toxic fumes of hydrogen chloride.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Mouse oral 1.06 mg/kg
- Inhalation: LC50 Rat inhalation >3.0 mg/L/1 hr
- Dermal: LD50 Albino rabbit percutaneous 200 mg/kg
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance may cause effects on the blood. This may result in bleeding. The effects may be delayed. Medical observation is indicated. See Notes. Exposure could cause death.
STOT-repeated exposure
The substance may have effects on the blood. This may result in bleeding.
Aspiration hazard
A harmful concentration of airborne particles can be reached quickly when dispersed.
SECTION 12: Ecological information
Toxicity
- Toxicity to fish: LC50; Species: Lepomis macrochirus (Bluegill); Conditions: freshwater, flow through; Concentration: 710 ug/L for 96 hr (95% confidence interval: 630-830 ug/L) /100% purity
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, flow through; Concentration: 640 ug/L for 48 hr (95% confidence interval: 540-820 ug/L); Effect: intoxication, immobilization /100% purity
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: Using OECD 301F (manometric respirometry test) with an activated sewage sludge inoculum, no biodegradation of chlorophacinone was observed after an incubation period of 28 days classifying the compound as not readily biodegradable under the conditions of the test(1). Chlorophacinone was found to be moderately degradable in a sandy loam soil under aerobic conditions with a half-life of 21-25 days(2). In laboratory tests conducted at 25 deg C under dark aerobic conditions using a sandy clay loam soil and a sandy loam soil, chlorophacinone had half-lives of 47.3 and 17.1 days respectively(1); extrapolation of the 47.3 day half-life to 12 deg C (to reflect an average European Union outdoor temperature) yields an estimated half-life of 128 days(1); degradation of the chlorophacinone resulted predominantly in the formation of carbon dioxide(1).
Bioaccumulative potential
An estimated BCF range of 5-13 was calculated in fish for chlorophacinone(SRC), using a measured log Kow range of 2.40-3.08(1) over a pH range of 4-9 and a regression-derived equation(2). According to a classification scheme(3), this BCF range suggests the potential for bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
Koc values ranging from 15,600 to 136,000 were determined for chlorophacinone in four types of soils (clay, sand, sandy clay loam and loam)(1). According to a classification scheme(2), this Koc range suggests that chlorophancinone is expected to be immobile in soil. The pKa of chlorophacinone is 3.40(3), indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). [
Other adverse effects
no data available
SECTION 13: Disposal considerations
Disposal methods
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
UN Number
ADR/RID: UN2761 (For reference only, please check.)
IMDG: UN2761 (For reference only, please check.)
IATA: UN2761 (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: ORGANOCHLORINE PESTICIDE, SOLID, TOXIC (For reference only, please check.)
IMDG: ORGANOCHLORINE PESTICIDE, SOLID, TOXIC (For reference only, please check.)
IATA: ORGANOCHLORINE PESTICIDE, SOLID, TOXIC (For reference only, please check.)
Transport hazard class(es)
ADR/RID: 6.1 (For reference only, please check.)
IMDG: 6.1 (For reference only, please check.)
IATA: 6.1 (For reference only, please check.)
Packing group, if applicable
ADR/RID: I (For reference only, please check.)
IMDG: I (For reference only, please check.)
IATA: I (For reference only, please check.)
Environmental hazards
ADR/RID: Yes
IMDG: Yes
IATA: Yes
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
Safety, health and environmental regulations specific for the product in question
SECTION 16: Other information
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Depending on the degree of exposure, periodic medical examination is suggested.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.Do NOT take working clothes home.Isolate contaminated clothing by sealing in a bag or other container.