Trimethylhydroquinone

Synonym(s):1,4-Dihydroxy-2,3,5-trimethylbenzene;3,6-Dihydroxypseudocumene

CAS NO.：700-13-0
Empirical Formula: C9H12O2
Molecular Weight: 152.19
MDL number: MFCD00002346
EINECS: 211-838-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:08:57

What is Trimethylhydroquinone?

Chemical properties

off-white, tan or orange powder

The Uses of Trimethylhydroquinone

Trimethylhydroquinone is used for synthesizing vitamin E and used as medical intermediate.

The Uses of Trimethylhydroquinone

Trimethylhydroquinone is a key precursor for the synthesis of tocopherols (vitamin E) and (±)-madindolines.

Definition

ChEBI: 2,3,5-trimethylhydroquinone is a member of the class of hydroquinones that is hydroquinone substituted by methyl groups at positions 2, 3 and 5. It is a member of hydroquinones and a methylbenzene.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 16, p. 378, 1968 DOI: 10.1248/cpb.16.378

Safety Profile

Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Recrystallise the hydroquinone from water, under anaerobic conditions. [Beilstein 6 H 931, 6 IV 5997.]

Properties of Trimethylhydroquinone

Melting point:	169-172 °C (lit.)
Boiling point:	295 °C (759.8513 mmHg)
Density	0.9595 (rough estimate)
vapor pressure	0-0.017Pa at 20-50℃
refractive index	1.4464 (estimate)
Flash point:	191 °C
storage temp.	Inert atmosphere,Room Temperature
solubility	methanol: 0.1 g/mL, clear
form	Crystalline Powder
pka	11.28±0.28(Predicted)
color	Beige
Water Solubility	2 g/L (20 ºC)
BRN	1909183
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference	700-13-0(CAS DataBase Reference)
NIST Chemistry Reference	Trimethylhydroquinone(700-13-0)
EPA Substance Registry System	1,4-Benzenediol, 2,3,5-trimethyl- (700-13-0)

Safety information for Trimethylhydroquinone

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H315:Skin corrosion/irritation H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.