Chloramphenicol sodium succinate
Synonym(s):Chloramphenicol α-succinate;Chloramphenicol succinate sodium salt
- CAS NO.:982-57-0
- Empirical Formula: C15H15Cl2N2O8.Na
- Molecular Weight: 445.19
- MDL number: MFCD00083598
- EINECS: 213-568-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 13:37:16
What is Chloramphenicol sodium succinate?
Chemical properties
White or yellowish-white powder, hygroscopic
The Uses of Chloramphenicol sodium succinate
antibacterial, antirickettsial, inhibits protein synthesis
The Uses of Chloramphenicol sodium succinate
Chloramphenicol succinate sodium is the salt prepared from chloramphenicol succinate using the free carboxylic acid of the succinate which ionises and readily forms in weakly sodium hydroxide solutions. The sodium salt is the preferred formulation for pharmaceutical applications, providing a more readily soluble product. Chloramphenicol succinate is significantly less active than chloramphenicol but acts as a prodrug, forming chloramphenicol in the presence of succinate dehydrogenase.
The Uses of Chloramphenicol sodium succinate
Chloramphenicol Succinate Sodium is a derivative of Chloramphenicol (C325030) which are broad spectrum antibiotic obtained from cultures of the soil bacterium Streptomyces venezuelae. It has a broad spectrum of activity against Gram-positive and gram-negative bacteria. Antibacterial; antirickettsial.
What are the applications of Application
Chloramphenicol succinate sodium salt is a broad spectrum antibiotic which acts by interfering with bacterial protein synthesis
General Description
White powder.
General Description
Chloramphenicol sodium succinate is the water-solublesodium salt of the hemisuccinate ester of chloramphenicol.Because of the low solubility of chloramphenicol, the sodiumsuccinate is preferred for intravenous administration. Theavailability of chloramphenicol from the ester followingintravenous administration is estimated to be 70% to 75%; theremainder is excreted unchanged. Poor availability ofthe active form from the ester following intramuscular injectionprecludes attaining effective plasma levels of the antibioticby this route. Orally administered chloramphenicol orits palmitate ester actually gives higher plasma levels of theactive antibiotic than does intravenously administered chloramphenicolsodium succinate. Nonetheless, effectiveconcentrations are achieved by either route.
Air & Water Reactions
Freely soluble in water.
Fire Hazard
Flash point data for Chloramphenicol sodium succinate are not available, but Chloramphenicol sodium succinate is probably combustible.
Properties of Chloramphenicol sodium succinate
Melting point: | >42oC (dec.) |
storage temp. | -20°C Freezer, Under inert atmosphere |
solubility | H2O: soluble50mg/mL |
form | solid |
color | White to Off-White |
CAS DataBase Reference | 982-57-0(CAS DataBase Reference) |
EPA Substance Registry System | Chloramphenicol sodium succinate (982-57-0) |
Safety information for Chloramphenicol sodium succinate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H302:Acute toxicity,oral H351:Carcinogenicity |
Precautionary Statement Codes |
P202:Do not handle until all safety precautions have been read and understood. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for Chloramphenicol sodium succinate
InChIKey | RPLOPBHEZLFENN-HTMVYDOJSA-M |
Chloramphenicol sodium succinate manufacturer
Nectar Lifesciences Ltd
B. Shah & Sons
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