Chloramine-T trihydrate

Chemical properties

Chloramine-T trihydrate is a white to yellow crystalline powder with characteristic odor. It is an air sensitive and corrosive, cause eye and skin burns and chemical dangers: Chloramine T is known to explode on heating above 130°C (anhydrous). Chloramine T decomposes slowly under the influence of air producing chlorine (trihydrate). On heating or on contact with acids it decomposes and produce toxic gases.

Description

Chloramine-T is commercially available in the form of a trihydrate and is a stable white to pale yellow solid. Chloramine T Sodium Salt Trihydrate is a reagent for selective oxidation of methionine. It is used as an antibacterial agent; a topical antiseptic. Capable of oxidative cyclization to produce various heterocycles. Nitrene source for aziridinations and aminohydroxylations. Reactant for Preparation of factor Xa inhibitors as novel anticoagulants.

The Uses of Chloramine-T trihydrate

Chloramine-T trihydrate can be used for detection of bromate and halogens.

The Uses of Chloramine-T trihydrate

Detection of bromate and halogens. Source of halonium ions and nitrogen anions in organic synthesis.

The Uses of Chloramine-T trihydrate

Chloramine-T trihydrate is used as an intermediate in the manufacture of chemical substances such as pharmaceuticals. It combines with iodogen or lactoperoxidase and is commonly used for labeling peptides and proteins with radioiodine isotopes. Hypochlorite released from chloramine-T acts as an effective oxidizing agent for iodide to form iodine monochloride (ICl).

General Description

Chloramine T (CAT) trihydrate is a commonly used reagent for organic synthesis especially in heterocyclic chemistry. CAT is an active chlorine compound that shows antimicrobial activity.

Advantage

Chloramine-T trihydrate's inexpensive, has low toxicity and acts as a oxidizing agent.

Hazards

Chloramine-T trihydrate is harmful if swallowed. It is corrosive on skin, eyes or mucous membranes. It releases toxic chlorine gas upon reaction with acids. It is a known sensitizer. Chloramine-T has been observed to cause occupational asthma and flu-like symptoms.

Purification Methods

Recrystallise it from hot water (2mL/g). Dry it in a desiccator over CaCl2 where it loses water. Protect it from sunlight. It is used for the detection of bromate and halogens, and Co, Cr, Fe, Hg, Mn, Ni and Sb ions. [Campbell & Johnson Chem Rev 78 65 1978, Bremner Synthetic Reagents 6 9 1985, Chattaway J Chem Soc 87 145 I1905, Inglis J Soc Chem Ind (Lond) 37 288 1918, Beilstein 11 H 107, 11 I 29, 11 II 62, 11 III 300, 2 IV 457.]