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HomeProduct name listCefozopran hydrochloride

Cefozopran hydrochloride

  • CAS NO.:113981-44-5
  • Empirical Formula: C19H18ClN9O5S2
  • Molecular Weight: 551.98
  • MDL number: MFCD00944908
  • EINECS: 1806241-263-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
Cefozopran hydrochloride Structural

What is Cefozopran hydrochloride?

Antimicrobial activity

Cefazolam hydrochloride is suitable for Staphylococcus, Streptococcus, Enterococcus, Peptostreptococcus, Escherichia coli, Enterobacter, Serratia, Klebsiella, Citrobacter, Proteus, Pseudomonas, Influenza Bacillus, Acinetobacter, Bacteroidetes, septicemia caused by sensitive bacteria to cefazolam hydrochloride, trauma infection, respiratory system, urinary system and abdominal cavity, pelvic purulent inflammation, ophthalmology and ENT inflammation, etc.

Biological Activity

Cefozopran (SCE-2787) hydrochloride is a semi-synthetic, parenteral, fourth-generation cephalosporin. As an antibiotic, it has broad-spectrum antibacterial activity and can inhibit most Gram-negative and Gram-positive bacteria.

in vitro

Cefozopran (SCE-2787) is a fourth-generation cephalosporin that has good activity against gram-positive organisms including methicillin-susceptible staphylococci, enterococci, and viridans group streptococci; and against gram-negative organisms including hemophilus influenza. Moreover, cefozopran has comparatively good activity against enterococci and P. aeruginosa , which are refractory to other cephalosporins.

in vivo

Cefozopran (SCE-2787) (5-80 mg/kg; sc; twice a day for 5 days; four-week-old ICR male mice) is effective against acute respiratory tract infections caused by Kiebsiella pneumonia DT-S. In the model of chronic respiratory tract infection caused by K. pneumoniae 27, Cefozopran (20-80 mg/kg; sc; twice a day for 7 days; five-week-old CBA/J female mice) is as effective as Ceftazidime.

Properties of Cefozopran hydrochloride

storage temp.  under inert gas (nitrogen or Argon) at 2-8°C
form  Solid
color  White to light yellow
Water Solubility  Water : ≥ 52 mg/mL (94.20 mM)

Safety information for Cefozopran hydrochloride

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Cefozopran hydrochloride

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