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HomeProduct name listCefotiam hydrochloride

Cefotiam hydrochloride

Synonym(s):;(6R,7R)-7-[[2-(2-Amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]-thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride hydrate;Cefotiam dihydrochloride

  • CAS NO.:66309-69-1
  • Empirical Formula: C18H23N9O4S3.HCl
  • Molecular Weight: 562.08
  • MDL number: MFCD01682052
  • EINECS: 266-312-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
Cefotiam hydrochloride Structural

What is Cefotiam hydrochloride?

Description

Cefotiam was synthesized by Takeda Chemicals Industries in 1977 as the first cephem derivative to introduce the aminothiazol group in the 7 side chain and the alkylated tetrazole group at the 3 side chain . This drug shows greater antibacterial activity against gram-negative bacteria than the earlier cephalosporins, including Enterobacter, Citrobacter, and indole-positive Proteus, and it retains the same activity as they have against gram-positive organisms. Its excellent activity against Klebsiella and Escherichia coli is based on its ability to penetrate the cell. This is 3- to 70-fold greater than that of cephalothin or cefazolin.

The Uses of Cefotiam hydrochloride

Cefotiam hydrochloride (SCE-963 hydrochloride) is a parenteral cephalosporin antibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria.

What are the applications of Application

Cefotiam Dihydrochloride is a cephalosporin antibiotic

Definition

ChEBI: Cefotiam dihydrochloride is the dihydrochloride salt of cefotiam. It has a role as an antibacterial drug. It contains a cefotiam.

brand name

Ceradon (Takeda).

Pharmacokinetics

Cefotiam Hydrochloride is the hydrochloride salt form of cefotiam, a third-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefotiam binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted.

Properties of Cefotiam hydrochloride

Melting point: >93°C (dec.)
Boiling point: 94℃
RTECS  XI0367000
Flash point: >110°(230°F)
storage temp.  Inert atmosphere,2-8°C
solubility  H2O: ≥22M
form  powder
color  white to tan
Water Solubility  Soluble in water
Stability: Hygroscopic
CAS DataBase Reference 66309-69-1(CAS DataBase Reference)

Safety information for Cefotiam hydrochloride

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H319:Serious eye damage/eye irritation
Precautionary Statement Codes P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Cefotiam hydrochloride

InChIKey BWRRTAXZCKVRON-DGPOFWGLSA-N

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