Cefotiam hydrochloride
Synonym(s):;(6R,7R)-7-[[2-(2-Amino-4-thiazolyl)acetyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl]-thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrochloride hydrate;Cefotiam dihydrochloride
- CAS NO.:66309-69-1
- Empirical Formula: C18H23N9O4S3.HCl
- Molecular Weight: 562.08
- MDL number: MFCD01682052
- EINECS: 266-312-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is Cefotiam hydrochloride?
Description
Cefotiam was synthesized by Takeda Chemicals Industries in 1977 as the first cephem derivative to introduce the aminothiazol group in the 7 side chain and the alkylated tetrazole group at the 3 side chain . This drug shows greater antibacterial activity against gram-negative bacteria than the earlier cephalosporins, including Enterobacter, Citrobacter, and indole-positive Proteus, and it retains the same activity as they have against gram-positive organisms. Its excellent activity against Klebsiella and Escherichia coli is based on its ability to penetrate the cell. This is 3- to 70-fold greater than that of cephalothin or cefazolin.
The Uses of Cefotiam hydrochloride
Cefotiam hydrochloride (SCE-963 hydrochloride) is a parenteral cephalosporin antibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria.
What are the applications of Application
Cefotiam Dihydrochloride is a cephalosporin antibiotic
Definition
ChEBI: Cefotiam dihydrochloride is the dihydrochloride salt of cefotiam. It has a role as an antibacterial drug. It contains a cefotiam.
brand name
Ceradon (Takeda).
Pharmacokinetics
Cefotiam Hydrochloride is the hydrochloride salt form of cefotiam, a third-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefotiam binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted.
Properties of Cefotiam hydrochloride
Melting point: | >93°C (dec.) |
Boiling point: | 94℃ |
RTECS | XI0367000 |
Flash point: | >110°(230°F) |
storage temp. | Inert atmosphere,2-8°C |
solubility | H2O: ≥22M |
form | powder |
color | white to tan |
Water Solubility | Soluble in water |
Stability: | Hygroscopic |
CAS DataBase Reference | 66309-69-1(CAS DataBase Reference) |
Safety information for Cefotiam hydrochloride
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Cefotiam hydrochloride
InChIKey | BWRRTAXZCKVRON-DGPOFWGLSA-N |
Abamectin manufacturer
Nectar Lifesciences Ltd
Aruvi Labs
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